Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Japan and Department of Computing and Information Systems, The University of Melbourne, Victoria, Australia.
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Japan and Department of Computing and Information Systems, The University of Melbourne, Victoria, Australia Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Japan and Department of Computing and Information Systems, The University of Melbourne, Victoria, Australia.
Bioinformatics. 2014 Nov 1;30(21):3139-41. doi: 10.1093/bioinformatics/btu501. Epub 2014 Jul 28.
NetPathMiner is a general framework for mining, from genome-scale networks, paths that are related to specific experimental conditions. NetPathMiner interfaces with various input formats including KGML, SBML and BioPAX files and allows for manipulation of networks in three different forms: metabolic, reaction and gene representations. NetPathMiner ranks the obtained paths and applies Markov model-based clustering and classification methods to the ranked paths for easy interpretation. NetPathMiner also provides static and interactive visualizations of networks and paths to aid manual investigation.
The package is available through Bioconductor and from Github at http://github.com/ahmohamed/NetPathMiner.
NetPathMiner 是一个从基因组规模网络中挖掘与特定实验条件相关路径的通用框架。NetPathMiner 与各种输入格式(包括 KGML、SBML 和 BioPAX 文件)接口,允许以三种不同形式操作网络:代谢、反应和基因表示。NetPathMiner 对获得的路径进行排序,并对排序后的路径应用基于马尔可夫模型的聚类和分类方法,以便于解释。NetPathMiner 还提供网络和路径的静态和交互式可视化,以帮助手动调查。
该软件包可通过 Bioconductor 获得,并可从 Github 上的 http://github.com/ahmohamed/NetPathMiner 获得。