某些水仙属植物提取物的体外细胞毒性
In vitro cytotoxicity of some Narcissus plants extracts.
作者信息
Shawky Eman, Abou-Donia Amina H, Darwish Fikria A, Toaima Soad M, Takla Sarah S, Al Asaar Mahmoud Mohamed
机构信息
a Department of Pharmacognosy , Faculty of Pharmacy, University of Alexandria , Alkhartoom Square, Alexandria 21521 , Egypt.
出版信息
Nat Prod Res. 2015;29(4):363-5. doi: 10.1080/14786419.2014.942302. Epub 2014 Jul 30.
This study compares the chloroform extracts of bulbs and roots of Narcissus papyraceus Ker Gawl. and Narcissus tazetta L. The cytotoxicity of the plant extracts was evaluated against human hepatocellular carcinoma cell line (HEPG2) and colon carcinoma cell line (HCT116) in comparison to doxorubicin. The extracts from the after-flowering (AF) bulbs of N. tazetta L. and N. papyraceus exhibited strong cytotoxic activity against HEPG2 (IC50: 2.2, 3.5 μg mL(-1)) and HCT116 (IC50: 4.2, 3.9 μg mL(-1)) cell lines, respectively. N. tazetta L. bulbs exhibited the least cell viability percentage in HepG-2 cell line (5.32%), while the AF root extracts of N. papyraceus exhibited the least cell viability percentage in HCT116 cell line (4.93%), when applied at a concentration of 50 μg mL(-1), thereby being more active than doxorubicin at the same concentration.
本研究比较了纸白水仙（Narcissus papyraceus Ker Gawl.）和水仙（Narcissus tazetta L.）鳞茎与根的氯仿提取物。与阿霉素相比，评估了植物提取物对人肝癌细胞系（HEPG2）和结肠癌细胞系（HCT116）的细胞毒性。纸白水仙和水仙开花后（AF）鳞茎的提取物分别对HEPG2（IC50：2.2、3.5 μg mL(-1)）和HCT116（IC50：4.2、3.9 μg mL(-1)）细胞系表现出较强的细胞毒性活性。当以50 μg mL(-1)的浓度应用时，水仙鳞茎在HepG-2细胞系中的细胞活力百分比最低（5.32%），而纸白水仙AF根提取物在HCT116细胞系中的细胞活力百分比最低（4.93%），因此在相同浓度下比阿霉素更具活性。
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