来自北部湾红树林植物白骨壤果实的新型抗氧化次生代谢产物。

New antioxidative secondary metabolites from the fruits of a Beibu Gulf mangrove, Avicennia marina.

作者信息

Gao Cheng-Hai, Yi Xiang-Xi, Xie Wen-Pei, Chen Yin-Ning, Xu Ming-Ben, Su Zhi-Wei, Yu Lian, Huang Ri-Ming

机构信息

Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China.

School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China.

出版信息

Mar Drugs. 2014 Jul 29;12(8):4353-60. doi: 10.3390/md12084353.

DOI:10.3390/md12084353

PMID:25076062

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4145320/

Abstract

Further chemical investigation of the fruits of the mangrove, Avicennia marina, afforded three new phenylethyl glycosides, marinoids J-L (1-3), and a new cinnamoyl glycoside, marinoid M (4). The structures of isolates were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related secondary metabolites. The antioxidant activity of the isolates was evaluated using the cellular antioxidant assay (CAA), and compounds 1-4 showed antioxidant activities, with EC50 values ranging from 23.0 ± 0.71 μM to 247.8 ± 2.47 μM.

摘要

对红树植物白骨壤果实进行进一步的化学研究，得到了三种新的苯乙基糖苷类化合物，即海榄雌素J-L（1-3），以及一种新的肉桂酰糖苷类化合物，海榄雌素M（4）。通过广泛的光谱分析，并将数据与相关次生代谢产物的数据进行比较，阐明了分离物的结构。使用细胞抗氧化试验（CAA）评估了分离物的抗氧化活性，化合物1-4表现出抗氧化活性，其半数有效浓度（EC50）值在23.0±0.71μM至247.8±2.47μM之间。