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门诊治疗创伤后应激障碍的疗效:一项随机对照临床试验。

Efficacy of an outpatient treatment for prolonged grief disorder: a randomized controlled clinical trial.

机构信息

Department of Psychology, Ludwig-Maximilian-University of Munich, Germany; Catholic University Eichstätt-Ingolstadt, Ostenstr. 25, D-85071 Eichstätt, Germany.

Department of Psychology, Ludwig-Maximilian-University of Munich, Germany.

出版信息

J Affect Disord. 2014;167:56-63. doi: 10.1016/j.jad.2014.05.035. Epub 2014 Jun 2.

Abstract

BACKGROUND

Abnormal forms of grief, currently referred to as complicated grief or prolonged grief disorder, have been discussed extensively in recent years. While the diagnostic criteria are still debated, there is no doubt that prolonged grief is disabling and may require treatment. To date, few interventions have demonstrated efficacy.

METHODS

We investigated whether outpatients suffering from prolonged grief disorder (PGD) benefit from a newly developed integrative cognitive behavioural therapy for prolonged grief (PG-CBT). A total of 51 patients were randomized into two groups, stratified by the type of death and their relationship to the deceased; 24 patients composed the treatment group and 27 patients composed the wait list control group (WG). Treatment consisted of 20-25 sessions. Main outcome was change in grief severity; secondary outcomes were reductions in general psychological distress and in comorbidity.

RESULTS

Patients on average had 2.5 comorbid diagnoses in addition to PGD. Between group effect sizes were large for the improvement of grief symptoms in treatment completers (Cohen׳s d=1.61) and in the intent-to-treat analysis (d=1.32). Comorbid depressive symptoms also improved in PG-CBT compared to WG. The completion rate was 79% in PG-CBT and 89% in WG.

LIMITATIONS

The major limitations of this study were a small sample size and that PG-CBT took longer than the waiting time.

CONCLUSIONS

PG-CBT was found to be effective with an acceptable dropout rate. Given the number of bereaved people who suffer from PGD, the results are of high clinical relevance.

摘要

背景

近年来,异常形式的悲伤,目前被称为复杂悲伤或延长哀伤障碍,已经被广泛讨论。虽然诊断标准仍存在争议,但毫无疑问,延长哀伤是使人丧失能力的,可能需要治疗。迄今为止,很少有干预措施显示出疗效。

方法

我们研究了患有延长哀伤障碍(PGD)的门诊患者是否受益于新开发的延长哀伤认知行为治疗(PG-CBT)。共有 51 名患者被随机分为两组,按死亡类型和与死者的关系分层;24 名患者组成治疗组,27 名患者组成等待名单对照组(WG)。治疗包括 20-25 次疗程。主要结局是悲伤严重程度的变化;次要结局是一般心理困扰和合并症的减少。

结果

患者平均除 PGD 外还有 2.5 种合并诊断。治疗完成者的悲伤症状改善的组间效应大小较大(Cohen's d=1.61),意向治疗分析的效应大小也较大(d=1.32)。与 WG 相比,PG-CBT 也改善了合并的抑郁症状。PG-CBT 的完成率为 79%,WG 为 89%。

局限性

本研究的主要局限性是样本量小,PG-CBT 耗时超过等待时间。

结论

PG-CBT 被发现是有效的,具有可接受的脱落率。鉴于有许多丧亲的人患有 PGD,这些结果具有很高的临床意义。

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