伊朗德黑兰孕妇亚临床甲状腺功能减退症的患病率
Prevalence of subclinical hypothyroidism in pregnant women in tehran-iran.
作者信息
Yassaee Fakhrolmolouk, Farahani Masoumeh, Abadi Ali Reza
机构信息
Department of Obstetrics and Gynecology, Taleghani University Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran ; Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Genomic Research Center, Infertility and Health Reseach Center, Tehran, Iran.
Department of Community Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Int J Fertil Steril. 2014 Jul;8(2):163-6. Epub 2014 Jul 8.
BACKGROUND
Maternal subclinical hypothyroidism during pregnancy is associated with various adverse outcomes. Recent consensus guidelines advocate universal thyroid function screening during pregnancy. There are no data from Iran about the prevalence of thyroid hypofunction in pregnancy. This study aims to find the prevalence of thyroid dysfunction.
MATERIALS AND METHODS
In this descriptive cross sectional study, thyrotropin (TSH) was measured in 3158 pregnant women irrespective of gestational age from October 2008-March 2012. If TSH was more than 2.5 mIU/L in the first trimester or more than 3 mIU/L in the second or third trimester, free T4 was measured to diagnose subclinical/ overt hypothyroidism. If serum free T4 was in the normal range (0.7-1.8 ng/dl) the diagnosis was subclinical hypothyroidism and if below the normal range, overt hypothyroidism was diagnosed.
RESULTS
A total of 3158 pregnant women were evaluated. One hundred forty seven of them were diagnosed as hypothyroidism. Subclinical hypothyroidism and overt hypothyroidism were present in 131 (89.1%) and 16 (10.9%) women respectively. Prevalence of subclinical hypothyroidism was 4.15%. Most of the subclinical and overt hypothyroidism cases were diagnosed in the first trimester.
CONCLUSION
It appears logical to check TSH during pregnancy due to the observed prevalence of subclinical hypothyroidism.
背景
孕期母体亚临床甲状腺功能减退与多种不良结局相关。近期的共识指南提倡孕期进行普遍的甲状腺功能筛查。伊朗尚无关于孕期甲状腺功能减退患病率的数据。本研究旨在确定甲状腺功能障碍的患病率。
材料与方法
在这项描述性横断面研究中，于2008年10月至2012年3月期间对3158名孕妇进行促甲状腺激素（TSH）检测，无论其孕周如何。如果孕早期TSH大于2.5 mIU/L或孕中期或孕晚期大于3 mIU/L，则检测游离T4以诊断亚临床/显性甲状腺功能减退。如果血清游离T4在正常范围（0.7 - 1.8 ng/dl），则诊断为亚临床甲状腺功能减退；如果低于正常范围，则诊断为显性甲状腺功能减退。
结果
共评估了3158名孕妇。其中147人被诊断为甲状腺功能减退。亚临床甲状腺功能减退和显性甲状腺功能减退分别存在于131名（89.1%）和16名（10.9%）女性中。亚临床甲状腺功能减退的患病率为4.15%。大多数亚临床和显性甲状腺功能减退病例在孕早期被诊断出来。
结论
鉴于观察到的亚临床甲状腺功能减退患病率，孕期检查TSH似乎是合理的。
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