[醛糖还原酶抑制剂对大鼠半乳糖性白内障预防作用的形态学分类]

[Morphological classification of the prevention by aldose reductase inhibitor of rat galactosemic cataract].

作者信息

Akagi Y, Ikebe H, Terubayashi H, Takahashi Y, Tsuji T

出版信息

Nippon Ganka Gakkai Zasshi. 1989 Apr;93(4):494-500.

Abstract

A morphological classification indicating the stage of the prevention of aldose reductase inhibitor (ARI) on the rat galactosemic cataract was investigated. Three week old rats (body weight 50 g) were fed with a 25% galactose diet. Two kinds of ARIs (ADN-138, FR-74366) were used with a different dose 25% galactose fed each drug. The rats on the 25% galactose diet rapidly developed cataracts in the equatorial region of the lens followed by total cataracts. The morphological processes of the galactose cataracts receiving preventive treatment of ARI were divided into 5 types according to their intensity.

摘要

研究了一种形态学分类方法，该方法用于指示醛糖还原酶抑制剂（ARI）对大鼠半乳糖性白内障预防的阶段。给3周龄（体重50克）的大鼠喂食25%的半乳糖饮食。使用两种ARI（ADN - 138、FR - 74366），每种药物在喂食25%半乳糖时采用不同剂量。喂食25%半乳糖饮食的大鼠晶状体赤道区迅速出现白内障，随后发展为完全性白内障。接受ARI预防性治疗的半乳糖性白内障的形态学过程根据其严重程度分为5种类型。