皮肤微生物群：皮肤病新型诊断和治疗方法的潜力。
The skin microbiome: potential for novel diagnostic and therapeutic approaches to cutaneous disease.
作者信息
Grice Elizabeth A
机构信息
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA. Email:
出版信息
Semin Cutan Med Surg. 2014 Jun;33(2):98-103. doi: 10.12788/j.sder.0087.
Abstract
A vast diversity of microorganisms, including bacteria, fungi, viruses, and arthropods, colonize the human skin. Culture-independent genomic approaches for identifying and characterizing microbial communities have provided glimpses into the topographical, temporal, and interpersonal complexity that defines the skin microbiome. Identification of changes associated with cutaneous disease, including acne, atopic dermatitis, rosacea, and psoriasis, are being established. In this review, our current knowledge of the skin microbiome in health and disease is discussed, with particular attention to potential opportunities to leverage the skin microbiome as a diagnostic, prognostic, and/or therapeutic tool.
摘要
包括细菌、真菌、病毒和节肢动物在内的各种各样的微生物寄居于人体皮肤。用于识别和表征微生物群落的非培养基因组方法，已让我们得以一窥定义皮肤微生物群的地形、时间和人际复杂性。与包括痤疮、特应性皮炎、酒渣鼻和银屑病在内的皮肤病相关的变化正在被确定。在本综述中，我们讨论了目前关于健康和疾病状态下皮肤微生物群的知识，尤其关注利用皮肤微生物群作为诊断、预后和/或治疗工具的潜在机会。
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本文引用的文献
1
Community differentiation of the cutaneous microbiota in psoriasis.
Microbiome. 2013 Dec 23;1(1):31. doi: 10.1186/2049-2618-1-31.
2
Culture-independent pilot study of microbiota colonizing open fractures and association with severity, mechanism, location, and complication from presentation to early outpatient follow-up.
J Orthop Res. 2014 Apr;32(4):597-605. doi: 10.1002/jor.22578. Epub 2014 Jan 3.
3
Microbial ecology of the skin in the era of metagenomics and molecular microbiology.
Cold Spring Harb Perspect Med. 2013 Dec 1;3(12):a015362. doi: 10.1101/cshperspect.a015362.
4
Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: implications of probiotics in acne vulgaris.
Appl Microbiol Biotechnol. 2014 Jan;98(1):411-24. doi: 10.1007/s00253-013-5394-8. Epub 2013 Nov 22.
5
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.
Nature. 2013 Dec 19;504(7480):451-5. doi: 10.1038/nature12726. Epub 2013 Nov 13.
6
The altered landscape of the human skin microbiome in patients with primary immunodeficiencies.
Genome Res. 2013 Dec;23(12):2103-14. doi: 10.1101/gr.159467.113. Epub 2013 Oct 29.
7
Functional characterisation of a SNP in the ABCC11 allele - effects on axillary skin metabolism, odour generation and associated behaviours.
J Dermatol Sci. 2014 Jan;73(1):23-30. doi: 10.1016/j.jdermsci.2013.08.016. Epub 2013 Sep 10.
8
Potential role of microorganisms in the pathogenesis of rosacea.
J Am Acad Dermatol. 2013 Dec;69(6):1025-32. doi: 10.1016/j.jaad.2013.08.006. Epub 2013 Sep 5.
9
Complement modulates the cutaneous microbiome and inflammatory milieu.
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15061-6. doi: 10.1073/pnas.1307855110. Epub 2013 Aug 26.
10
Characterization of Staphylococcus and Corynebacterium clusters in the human axillary region.
PLoS One. 2013 Aug 12;8(8):e70538. doi: 10.1371/journal.pone.0070538. eCollection 2013.
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