[经优福定、阿霉素、丝裂霉素治疗后不可切除的胃癌变为可根治性切除]

[An unresectable gastric cancer radically resectable following UFT, ADM, MMC therapy].

作者信息

Watarai N, Kataoka M, Hayashi S, Tsuji H, Kasugai T, Taniwaki S, Kureyama Y, Mitsui T, Masaoka A, Kamejima N

机构信息

Second Dept. of Surgery, Nagoya City University Medical School.

出版信息

Gan To Kagaku Ryoho. 1989 Oct;16(10):3467-71.

PMID:2508569

Abstract

A 58-year-old woman who was inoperable because of S3 (pancreas and colon) and P1 at the initial operation was treated with UFT, ADM and MMC at a dosage of 242.7 g, 418 mg and 166 mg, respectively. After the chemotherapy (2 years and 6 months from initial operation), a second look operation revealed that a tumor was localized in the submucosal layer and there were no lymph node metastases. Thus, it could be resected radically. Until now, various methods of chemotherapy for unresectable gastric cancer have been reported, and many cases of CR contained fluoropyrimidine derivates. In the case under study, combination chemotherapy containing UFT was performed with good results.

摘要

一名58岁女性，因初次手术时处于S3期（胰腺和结肠）及P1期而无法手术，接受了优福定（UFT）、阿霉素（ADM）和丝裂霉素（MMC）治疗，剂量分别为242.7克、418毫克和166毫克。化疗后（初次手术后2年6个月），再次手术发现肿瘤局限于黏膜下层，无淋巴结转移。因此，可以进行根治性切除。到目前为止，已经报道了多种针对不可切除胃癌的化疗方法，许多完全缓解（CR）病例都包含氟嘧啶衍生物。在本研究病例中，采用含优福定的联合化疗取得了良好效果。