Colombo Pierre-Emmanuel, Vincent-Salomon Anne, Chateau Marie-Christine, Mourregot Anne, Gutowski Marian, Laffargue Guillaume, Masson Bruno, Maran-Gonzalez Aurélie, Rouanet Philippe
ICM Val d'Aurelle, Département de chirurgie oncologique, 208, avenue des Apothicaires, Parc Euromédecine, 34298 Montpellier cedex 5, France.
Institut Curie, Département d'anatomopathologie, 26, rue d'Ulm, 75005 Paris, France.
Bull Cancer. 2014 Jul-Aug;101(7-8):718-29. doi: 10.1684/bdc.2014.2010.
Diagnostics of high-risk breast lesions have increased these last years with the augmentation of breast percutaneous biopsies. They are lesions that confer an enlarged risk of breast cancer, either because of an increased probability of finding cancer after open surgery, a possible evolution toward in situ or invasive cancer, or because of an increased probability of developing breast cancer over the long term. Much progress has been made these last years in their histological diagnostic, classification and pathogenesis. Nevertheless, no consensus exists to date on the management of these "high-risk" lesions. In particular, surgical indications and follow-up modalities remain controversial for each histological type. In this review, the principal factors that could impact surgical decision and long-term follow-up are discussed with areas of controversy highlighted.