Han Jiyeon, Lee Eunkyung, Kim EunJoo, Yeom Myung Hun, Kwon Ohsang, Yoon Tae Hong, Lee Tae Ryong, Kim Kwangmi
R&D Unit, AmorePacific Corporation, Yongin-si, Gyeonggi-do, Korea.
Exp Dermatol. 2014 Nov;23(11):860-2. doi: 10.1111/exd.12531.
Ginsenoside F1 (GF1) is a metabolite of ginsenoside Rg1. Although GF1 has several benefits for skin physiology, the effect of GF1 on skin pigmentation has not been reported. We found that a cream containing 0.1% GF1 showed a significant whitening effect on artificially tanned human skin after 8 weeks of application. However, GF1 did not inhibit mRNA expression of tyrosinase or dopachrome tautomerase (DCT) in normal human epidermal melanocytes (NHEMs) or cocultured NHEMs/normal human epidermal keratinocytes. Interestingly, GF1 enhanced production of interleukin 13 (IL-13) from human epidermal γδ T cells. IL-13 significantly reduced the mRNA expression and protein amount of both tyrosinase and DCT and reduced melanin synthesis activities in NHEMs, resulting in visible brightening of NHEM pellet. These results suggest that enhancement of IL-13 production by GF1 from epidermal γδ T cells might play a role in the skin-whitening effect of GF1 via the suppression of tyrosinase and DCT.
人参皂苷F1（GF1）是人参皂苷Rg1的一种代谢产物。尽管GF1对皮肤生理有诸多益处，但尚未见关于GF1对皮肤色素沉着影响的报道。我们发现，含0.1%GF1的乳膏在应用8周后对人工晒黑的人体皮肤有显著美白效果。然而，GF1在正常人表皮黑素细胞（NHEM）或共培养的NHEM/正常人表皮角质形成细胞中并未抑制酪氨酸酶或多巴色素互变酶（DCT）的mRNA表达。有趣的是，GF1可增强人表皮γδT细胞白细胞介素13（IL-13）的产生。IL-13显著降低NHEM中酪氨酸酶和DCT的mRNA表达及蛋白量，并降低NHEM中的黑色素合成活性，从而使NHEM沉淀明显变亮。这些结果表明，GF1通过表皮γδT细胞增强IL-13的产生可能通过抑制酪氨酸酶和DCT在GF1的皮肤美白作用中发挥作用。
