Kloprogge E, de Leeuw A J, de Monchy J G, Kauffman H F
Department of Allergology, University Hospital, Groningen, The Netherlands.
Int Arch Allergy Appl Immunol. 1989;90(1):20-3. doi: 10.1159/000234994.
Eosinophilic granulocytes as well as neutrophilic granulocytes produced leukotriene C4 (LTC4) on stimulation with 1 microM A23187 (Ca2+ ionophore). In healthy volunteers, the LTC4 production in eosinophils was about 3 times the production in neutrophils. Within 15 min greater than 90% of the LTC4 was released into the supernatant. Stimulation of eosinophils and neutrophils together resulted in a synergistic increase in LTC4 production of 306 +/- 40%. LTC4 synthesis by hypodense eosinophils was also enhanced if stimulated in the presence of neutrophils. These findings suggest a communication between eosinophils and neutrophils, which may play a role in bronchial asthma.
嗜酸性粒细胞以及嗜中性粒细胞在受到1微摩尔A23187（钙离子载体）刺激时会产生白三烯C4（LTC4）。在健康志愿者中，嗜酸性粒细胞中LTC4的产生量约为嗜中性粒细胞中产生量的3倍。在15分钟内，超过90%的LTC4释放到上清液中。嗜酸性粒细胞和嗜中性粒细胞共同受到刺激会导致LTC4产生量协同增加306±40%。如果在嗜中性粒细胞存在的情况下刺激低密度嗜酸性粒细胞，其LTC4合成也会增强。这些发现表明嗜酸性粒细胞和嗜中性粒细胞之间存在交流，这可能在支气管哮喘中起作用。
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