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[源自食物蛋白质的具有心脏保护特性的生物活性肽作为食物成分]

[Biologically active peptides derived from food proteins as the food components with cardioprotective properties].

作者信息

Iwaniak Anna, Darewicz Małgorzata, Minkiewicz Piotr, Protasiewicz Monika, Borawska Justyna

出版信息

Pol Merkur Lekarski. 2014 Jun;36(216):403-6.

Abstract

Food proteins are the source of peptides with many biological activities. One of them is their impact on blood circulatory system. This group of peptides includes the ones with the ability to reduce the blood pressure (inhibitors of angiotensin converting enzyme--ACE), antithrombotic, and to lower the cholesterol level. Among the above-mentioned peptides' bioactivities, the most of them act as the ACE inhibitors. Some of them are the functional food components and nutraceuticals and possess the status of food with special use. The main known source of antithrombotic and cholesterol lowering peptides are milk and soy proteins, respectively. However, the scientists make the efforts to find new alternative sources of peptides with the above-mentioned activities. It should be noted, that although the bioactive peptides are considered as the safe food components and thus be supportive in the cardiovascular diseases therapy, they cannot substitute the drugs. This review shows the characteristics of selected peptides with: blood pressure reducing, antithrombotic, and cholesterol level reducing activities. We focused on the sequences that were identified in food proteins as well as were tested on humans or animals.

摘要

食物蛋白是具有多种生物活性的肽的来源。其中之一是它们对血液循环系统的影响。这类肽包括具有降低血压能力的肽(血管紧张素转换酶抑制剂——ACE)、抗血栓形成的肽以及降低胆固醇水平的肽。在上述肽的生物活性中,它们大多作为ACE抑制剂起作用。其中一些是功能性食品成分和营养保健品,并具有特殊用途食品的地位。抗血栓形成肽和降低胆固醇肽的主要已知来源分别是牛奶和大豆蛋白。然而,科学家们正在努力寻找具有上述活性的肽的新替代来源。应该指出的是,尽管生物活性肽被认为是安全的食品成分,因此在心血管疾病治疗中具有辅助作用,但它们不能替代药物。本综述展示了具有降血压、抗血栓形成和降低胆固醇水平活性的特定肽的特性。我们关注的是在食物蛋白中鉴定出的以及在人类或动物身上进行过测试的序列。

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