内脏利什曼病和皮肤利什曼病患者血清硒、锌和铜水平的比较。
A comparison of serum selenium, zinc and copper level in visceral and cutaneous leishmaniasis.
作者信息
Farzin Leila, Moassesi Mohammad Esmail
机构信息
Environmental Laboratory, Nuclear Science Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Tehran, Iran.
出版信息
J Res Med Sci. 2014 Apr;19(4):355-7.
BACKGROUND
Leishmaniasis is a widespread tropical infection, which has a high incidence rate in Iran. Visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are two forms of this disease. In this study, we investigated if selenium (Se), zinc (Zn) and copper (Cu) levels differ in different forms of leishmaniasis.
MATERIALS AND METHODS
To determine if leishmaniasis has effects on trace elements status, they were determined by atomic absorption spectrometry (AAS) in patients (n = 155, 95 CL and 60 VL) and control group (n = 100).
RESULTS
Our findings indicate that there is a significant difference in the values of Se and Zn between control and patient groups (P < 0.0001 and P < 0.001, respectively). Se and Zn levels were 3.65 ± 0.88 and 67.24 ± 18.76 μg/dL in the leishmaniasis patients, and these values were observed to be statistically lower compared to the control groups (11.10 ± 2.37 and 119.61 ± 26.18 μg/dL, respectively). Meanwhile, no significant difference in status of Cu was found between the cases (110.55 ± 29.25 μg/dL) and healthy subjects (91.42 ± 27.54 μg/dL) (P > 0.05). When the patients were divided into two groups, there appeared to be a significant decrease (P < 0.001) in Se concentration for VL patients (2.57 ± 0.64 μg/dL) compared with CL patients (4.33 ± 1.06 μg/dL).
CONCLUSION
Based on these results, serum Se and Zn levels could be a useful marker for the pathophysiology of leishmaniasis.
背景
利什曼病是一种广泛流行的热带感染病，在伊朗发病率很高。内脏利什曼病（VL）和皮肤利什曼病（CL）是该疾病的两种形式。在本研究中，我们调查了不同形式的利什曼病中硒（Se）、锌（Zn）和铜（Cu）水平是否存在差异。
材料与方法
为确定利什曼病是否对微量元素状态有影响，采用原子吸收光谱法（AAS）对患者（n = 155，其中95例为CL患者，60例为VL患者）和对照组（n = 100）进行了测定。
结果
我们的研究结果表明，对照组和患者组之间的Se和Zn值存在显著差异（分别为P < 0.0001和P < 0.001）。利什曼病患者的Se和Zn水平分别为3.65±0.88和67.24±18.76μg/dL，与对照组（分别为11.10±2.37和119.61±26.18μg/dL）相比，这些值在统计学上较低。同时，病例组（110.55±29.25μg/dL）和健康受试者（91.42±27.54μg/dL）之间的Cu状态无显著差异（P > 0.05）。当将患者分为两组时，与CL患者（4.33±1.06μg/dL）相比，VL患者（2.57±0.64μg/dL）的Se浓度似乎显著降低（P < 0.001）。
结论
基于这些结果，血清Se和Zn水平可能是利什曼病病理生理学的一个有用标志物。
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