Wang Chao, Xu Jin, Lou Wutao, Zhao Songzhen
The Key Laboratory of Biomedical Information of Ministry of Education, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
The Key Laboratory of Biomedical Information of Ministry of Education, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Neurosci Lett. 2014 Sep 19;580:108-13. doi: 10.1016/j.neulet.2014.07.056. Epub 2014 Aug 7.
This study investigated the information flow in patients with Vascular Dementia (VaD). Twelve VaD patients and twelve age-matched controls participated in the study. EEG signal was recorded when subjects were performing a visual oddball task. Information flow was analyzed between 9 electrodes in frontal, central, and parietal lobes using short-window Directed Transfer Function (sDTF). VaD patients presented a significant decline in the information flow from parietal to frontal and central lobes, compared with the healthy elderly. This decline mainly occurred in delta, theta, and lower alpha bands, from about 200ms to 300ms after target stimulus onset. The findings indicated an impaired parietal-to-frontal and parietal-to-central connectivity in VaD patients, which may be one reason for the cognitive deficits in VaD patients.
本研究调查了血管性痴呆（VaD）患者的信息流。12名VaD患者和12名年龄匹配的对照者参与了该研究。当受试者执行视觉oddball任务时记录脑电图信号。使用短窗口定向传递函数（sDTF）分析额叶、中央叶和顶叶的9个电极之间的信息流。与健康老年人相比，VaD患者从顶叶到额叶和中央叶的信息流显著下降。这种下降主要发生在目标刺激开始后约200毫秒至300毫秒的δ、θ和较低α频段。研究结果表明，VaD患者顶叶到额叶和顶叶到中央叶的连接受损，这可能是VaD患者认知缺陷的原因之一。
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