低剂量给予雄性大鼠的四十种致癌物的联合效应。
Combination effects of forty carcinogens administered at low doses to male rats.
作者信息
Takayama S, Hasegawa H, Ohgaki H
机构信息
National Cancer Center Research Institute, Chuo-ku, Tokyo.
出版信息
Jpn J Cancer Res. 1989 Aug;80(8):732-6. doi: 10.1111/j.1349-7006.1989.tb01706.x.
An investigation was conducted to determine whether a mixture of low doses of forty carcinogens that target different organs, including the liver, intestine, thyroid, urinary bladder, and skin, is effective for tumor induction in F344/DuCrj rats. The dose of each carcinogen in the diet was 1/50 of the TD50 value, treatment being continued for 102 weeks. Significant numbers of neoplastic nodules of the liver and follicular cell tumors of the thyroid developed in the animals exposed to the carcinogen mixture, although the question of whether the observed carcinogenic effects were synergistic or additive could not be answered. The results serve to evaluate carcinogenic risk in the search for causes of human cancer.
开展了一项调查，以确定低剂量的四十种针对不同器官（包括肝脏、肠道、甲状腺、膀胱和皮肤）的致癌物混合物，对F344/DuCrj大鼠诱发肿瘤是否有效。饮食中每种致癌物的剂量为半数致死剂量（TD50）值的1/50，治疗持续102周。接触致癌物混合物的动物出现了大量肝脏肿瘤结节和甲状腺滤泡细胞瘤，尽管无法回答所观察到的致癌作用是协同还是相加的问题。这些结果有助于评估致癌风险，以寻找人类癌症的病因。
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