Noppe Gerard, Van Rossum Elisabeth F C, Koper Jan Willem, Manenschijn Laura, Bruining G Jan, de Rijke Yolanda B, van den Akker Erica L T
Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Horm Res Paediatr. 2014;82(2):97-102. doi: 10.1159/000362519. Epub 2014 Aug 9.
Cortisol is produced in a circadian rhythm controlled by the hypothalamus-pituitary-adrenal axis, making it cumbersome to measure long-term cortisol exposure. Hair has proven to be a reliable matrix for long-term cortisol measurement in adults and can be used as diagnostic tool for (cyclic) Cushing's syndrome. The diagnostic applicability in children has not been studied, nor have the effects of development and hair care been evaluated in children. We aimed to establish reference ranges of hair cortisol concentrations (HCC) in healthy children and to evaluate the effects of age, gender, puberty and characteristics of hair care.
In 128 healthy children aged 4-14 years, HCC were measured in a small 3-cm hair lock from the back of the head.
HCC increased with age (p = 0.04) up to age 10 years, with a mean of 5.0, 5.8, 6.8 and 8.5 pg/mg at age 4-5, 6-7, 8-9 and 10-14 years, respectively. Children aged 4-7 years had significantly lower HCC compared to healthy adults (p = 0.007). We did not find any influence of gender, puberty or hair care characteristics on hair cortisol.
HCC can be reliably measured in childhood, and reference ranges increase with age. HCC in children are not dependent on hair care or hair characteristics.
皮质醇以昼夜节律的方式分泌，受下丘脑-垂体-肾上腺轴的控制，因此测量长期皮质醇暴露较为繁琐。头发已被证明是测量成年人长期皮质醇的可靠基质，可作为（周期性）库欣综合征的诊断工具。目前尚未研究其在儿童中的诊断适用性，也未评估发育和头发护理对儿童的影响。我们旨在确定健康儿童头发皮质醇浓度（HCC）的参考范围，并评估年龄、性别、青春期和头发护理特点的影响。
对128名4-14岁的健康儿童，测量其从后脑勺取的3厘米发束中的HCC。
HCC在10岁前随年龄增长而升高（p = 0.04），4-5岁、6-7岁、8-9岁和10-14岁儿童的HCC平均值分别为5.0、5.8、6.8和8.5 pg/mg。4-7岁儿童的HCC显著低于健康成年人（p = 0.007）。我们未发现性别、青春期或头发护理特点对头发皮质醇有任何影响。
儿童期可可靠地测量HCC，且参考范围随年龄增加。儿童的HCC不依赖于头发护理或头发特征。
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