Del Risco Kollerud R, Blaasaas K G, Claussen B
1] Agency for Health, City of Oslo, PO Box 4716 Storgate, 0506 Oslo, Norway [2] Institute of Health and Society, University of Oslo, PO Box 1130 Blindervn, 0318 Oslo, Norway.
Finance Norway, PO Box 2473 Solli, 0202 Oslo, Norway.
Br J Cancer. 2014 Sep 23;111(7):1413-20. doi: 10.1038/bjc.2014.400. Epub 2014 Aug 12.
Over the past few years, there has been growing interest in assessing the relationship between exposure to radon at home and the risk of childhood cancer. Previous studies have produced conflicting results, probably because of limitations assessing radon exposure, too few cancer cases and poorly documented health statistics.
We used a cohort approach of 0-15-year-old children to examine whether residential radon exposure was associated with childhood leukaemia and cancer in the central nervous system in the Oslo region. The study was based on Norwegian population registers and identified cancer cases from The Cancer Registry of Norway. The residence of every child was geo-coded and assigned a radon exposure.
In all, 712 674 children were followed from 1967 to 2009 from birth to date of cancer diagnosis, death, emigration or 15 years of age. A total of 864 cancer cases were identified, 437 children got leukaemia and 427 got cancer in the central nervous system.Conclusions or interpretation:No association was found for childhood leukaemia. An elevated nonsignificant risk for cancer in the central nervous system was observed. This association should be interpreted with caution owing to the crude exposure assessment and possibilities of confounding.
在过去几年中，人们对评估家庭中氡暴露与儿童癌症风险之间的关系越来越感兴趣。以往的研究结果相互矛盾，这可能是由于评估氡暴露存在局限性、癌症病例过少以及健康统计记录不完善所致。
我们采用队列研究方法，对奥斯陆地区0至15岁的儿童进行研究，以检验居住环境中的氡暴露是否与儿童白血病及中枢神经系统癌症有关。该研究基于挪威人口登记册，并从挪威癌症登记处识别出癌症病例。对每个孩子的居住地址进行地理编码，并确定其氡暴露情况。
从1967年到2009年，总共对712674名儿童进行了跟踪，从出生一直到癌症诊断、死亡、移民或年满15岁。总共识别出864例癌症病例，其中437名儿童患白血病，427名儿童患中枢神经系统癌症。
未发现儿童白血病与氡暴露之间存在关联。观察到中枢神经系统癌症存在非显著升高的风险。由于暴露评估粗略以及存在混杂因素的可能性，对这种关联应谨慎解读。
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