新型体外恒化器系统中生物膜细菌与抗生素的相互作用
Interaction of biofilm bacteria with antibiotics in a novel in vitro chemostat system.
作者信息
Anwar H, van Biesen T, Dasgupta M, Lam K, Costerton J W
机构信息
Department of Microbiology, University of Alberta, Edmonton, Canada.
出版信息
Antimicrob Agents Chemother. 1989 Oct;33(10):1824-6. doi: 10.1128/AAC.33.10.1824.
Abstract
Pseudomonas aeruginosa was cultivated at low growth rates under iron-limiting conditions on acrylic tiles. Biofilm cells exhibited increased tobramycin resistance compared with that of planktonic cells, and in old biofilms were more resistant than were cells in young biofilms. However, on suspension of the biofilm bacteria, glycocalyx-mediated resistance was lost.
摘要
铜绿假单胞菌在铁限制条件下于丙烯酸瓷砖上以低生长速率培养。与浮游细胞相比，生物膜细胞表现出对妥布霉素的抗性增加，并且在老化生物膜中的细胞比年轻生物膜中的细胞更具抗性。然而，当生物膜细菌悬浮时，糖萼介导的抗性丧失。
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