血清HER2胞外域作为转移性胃癌患者组织HER2状态的潜在替代指标。
Serum HER2 extracellular domain as a potential alternative for tissue HER2 status in metastatic gastric cancer patients.
作者信息
Peng Zhi, Liu Yi, Li Yanyan, Zhang Xiaotian, Zhou Jun, Lu Ming, Li Qingqing, Shen Lin
机构信息
Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
出版信息
Biomark Med. 2014;8(5):663-70. doi: 10.2217/bmm.14.10.
AIM
We investigated whether serum concentrations of the HER2 extracellular domain (ECD) can be used as an alternative to test tissue HER2 status in metastatic gastric cancer.
MATERIALS & METHODS: A total of 133 cases of metastatic gastric cancer were included in present study. Serum HER2 ECD was measured by chemiluminescence immunoassay (CLIA). Receiver operating characteristic curve analysis was used to determine optimal serum HER2 ECD concentrations for differentiation between positive and negative HER2 status.
RESULTS
The median level of serum HER2 ECD was 9.6 ng/ml in metastatic gastric cancer patients. There was a significant relationship between serum and tissue levels of HER2 protein (p < 0.001). Area under the curve for serum HER2 ECD was 0.771 (95% CI: 0.682-0.860).
CONCLUSION
Levels of serum HER2 ECD are highly correlated with tissue HER2 status in metastatic gastric cancer. Serum HER2 ECD assay can be considered as a potential alternative for tissue HER2 status.
目的
我们研究了血清中HER2细胞外结构域（ECD）浓度是否可作为检测转移性胃癌组织HER2状态的替代方法。
材料与方法
本研究共纳入133例转移性胃癌病例。采用化学发光免疫分析法（CLIA）检测血清HER2 ECD。采用受试者工作特征曲线分析来确定区分HER2状态阳性和阴性的最佳血清HER2 ECD浓度。
结果
转移性胃癌患者血清HER2 ECD的中位水平为9.6 ng/ml。HER2蛋白的血清水平与组织水平之间存在显著相关性（p < 0.001）。血清HER2 ECD的曲线下面积为0.771（95% CI：0.682 - 0.860）。
结论
转移性胃癌中血清HER2 ECD水平与组织HER2状态高度相关。血清HER2 ECD检测可被视为检测组织HER2状态的一种潜在替代方法。
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