Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden.
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden.
Cell Metab. 2014 Sep 2;20(3):396-407. doi: 10.1016/j.cmet.2014.07.005. Epub 2014 Aug 7.
Igniting thermogenesis within white adipose tissue (i.e., promoting expression and activity of the uncoupling protein UCP1) has attracted much interest. Numerous "browning agents" have now been described (gene ablations, transgenes, food components, drugs, environments, etc.). The implied action of browning agents is that they increase UCP1 through this heat production, leading to slimming. Here, we particularly point to the possibility that cause and effect may on occasion be the reverse: browning agents may disrupt, for example, the fur, leading to increased heat loss, increased thermogenic demand to counteract this heat loss, and thus, through sympathetic nervous system activation, to enhanced UCP1 expression in white (and brown) adipose tissues.
在内皮脂肪组织中引发产热（即促进解偶联蛋白 UCP1 的表达和活性）引起了广泛关注。现在已经描述了许多“褐色化剂”（基因缺失、转基因、食物成分、药物、环境等）。褐色化剂的作用是通过这种产热增加 UCP1，从而导致减肥。在这里，我们特别指出，有时因果关系可能相反：褐色化剂可能会破坏皮毛，导致热量损失增加，为了抵消这种热量损失，会增加产热需求，从而通过交感神经系统的激活，增强白色（和棕色）脂肪组织中 UCP1 的表达。
