Gujral Gina, Winckel Karl, Nissen Lisa M, Cottrell W Neil
School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia,
Int J Clin Pharm. 2014 Oct;36(5):1048-58. doi: 10.1007/s11096-014-9993-y. Epub 2014 Aug 19.
Adherence to evidence based medicines in patients who have experienced a myocardial infarction remains low. Individual's beliefs towards their medicines are a strong predictor of adherence and may influence other factors that impact on adherence.
To investigate if community pharmacists discussing patients' beliefs about their medicines improved medication adherence at 12 months post myocardial infarction.
This study included 200 patients discharged from a public teaching hospital in Queensland, Australia, following a myocardial infarction. Patients were randomised into intervention (n = 100) and control groups (n = 100) and followed for 12 months.
All patients were interviewed between 5 to 6 weeks, at 6 and 12 months post discharge by the researcher using the repertory grid technique. This technique was used to elicit the patient's individualised beliefs about their medicines for their myocardial infarction. In the intervention group, patients' beliefs about their medicines were communicated by the researcher to their community pharmacist. The pharmacist used this information to tailor their discussion with the patient about their medication beliefs at designated time points (3 and 6 months post discharge). The control group was provided with usual care.
The difference in non-adherence measured using a medication possession ratio between the intervention and control groups at 12 months post myocardial infarction.
There were 137 patients remaining in the study (intervention group n = 72, control group n = 65) at 12 months. In the intervention group 29 % (n = 20) of patients were non-adherent compared to 25 % (n = 16) of patients in control group.
Discussing patients' beliefs about their medicines for their myocardial infarction did not improve medication adherence. Further research on patients beliefs should focus on targeting non-adherent patients whose reasons for their non-adherence is driven by their medication beliefs.
心肌梗死患者对循证药物的依从性仍然很低。个人对药物的信念是依从性的有力预测指标,可能会影响其他影响依从性的因素。
调查社区药剂师与患者讨论其对药物的信念是否能提高心肌梗死后12个月的药物依从性。
本研究纳入了澳大利亚昆士兰州一家公立教学医院200例心肌梗死后出院的患者。患者被随机分为干预组(n = 100)和对照组(n = 100),并随访12个月。
研究人员在出院后5至6周、6个月和12个月时使用 repertory grid 技术对所有患者进行访谈。该技术用于引出患者对其心肌梗死药物的个性化信念。在干预组中,研究人员将患者对药物的信念传达给他们的社区药剂师。药剂师利用这些信息在指定时间点(出院后3个月和6个月)与患者就其用药信念进行针对性讨论。对照组接受常规护理。
心肌梗死后12个月时,干预组和对照组使用药物持有率测量的不依从性差异。
12个月时,有137名患者留在研究中(干预组n = 72,对照组n = 65)。干预组中29%(n = 20)的患者不依从,而对照组中这一比例为25%(n = 16)。
讨论患者对其心肌梗死药物的信念并不能提高药物依从性。关于患者信念的进一步研究应侧重于针对那些不依从原因由其用药信念驱动的不依从患者。