Department of Molecular and Cellular Biochemistry, Indiana University Bloomington, Bloomington, Indiana, USA.
Cubist Pharmaceuticals, Inc., Lexington, Massachusetts, USA.
J Clin Microbiol. 2014 Nov;52(11):4049-52. doi: 10.1128/JCM.02357-14. Epub 2014 Aug 20.
Ceftolozane MIC(50)/MIC(90)s were 4/8 μg/ml when tested against 26 CTX-M-14-type-producing isolates and 64/>64 μg/ml against 219 CTX-M-15-type-producing isolates. The addition of 4 μg/ml tazobactam lowered the ceftolozane MIC50/MIC9(0)s to ≤ 0.25/0.5 μg/ml by broth microdilution and Etest. The zone diameters for the ceftolozane-tazobactam disks were 23 to 29 mm for 92.2% of the isolates.
头孢洛扎他唑巴坦 MIC(50)/MIC(90)值对 26 株 CTX-M-14 型产酶株的检测结果分别为 4/8μg/ml,对 219 株 CTX-M-15 型产酶株的检测结果均≥64/64μg/ml。肉汤微量稀释法和 Etest 法检测结果显示,当添加 4μg/ml 他唑巴坦时,头孢洛扎他唑巴坦 MIC50/MIC90 值降低至≤0.25/0.5μg/ml。头孢洛扎他唑巴坦纸片的抑菌环直径对 92.2%的分离株为 23 至 29mm。