硫化氢，肾脏相关疾病中的一个新型治疗靶点？
H2S, a novel therapeutic target in renal-associated diseases?
作者信息
Pan Wen-Jun, Fan Wen-Jing, Zhang Chi, Han Dan, Qu Shun-Lin, Jiang Zhi-Sheng
机构信息
Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Post-doctoral Mobile Stations for Basic Medicine, University of South China, Hengyang City, Hunan Province 421001, PR China.
Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Post-doctoral Mobile Stations for Basic Medicine, University of South China, Hengyang City, Hunan Province 421001, PR China; The Second Affiliated Hospital, University of South China, Hengyang City, Hunan Province 421001, PR China.
出版信息
Clin Chim Acta. 2015 Jan 1;438:112-8. doi: 10.1016/j.cca.2014.08.005. Epub 2014 Aug 20.
For more than a century, hydrogen sulfide (H2S) has been regarded as a toxic gas. Recently, the understanding of the biological effects of H2S has been changed. This review surveys the growing recognition of H2S as an endogenous signaling molecule in mammals, with emphasis on its physiological and pathological pathways in the urinary system. This article reviews recent progress of basic and pharmacological researches related to endogenous H2S in urinary system, including the regulatory effects of H2S in the process of antioxidant, inflammation, cellular matrix remodeling and ion channels, and the role of endogenous H2S pathway in the pathogenesis of renal and urogenital disorders.
一个多世纪以来，硫化氢（H₂S）一直被视为一种有毒气体。最近，人们对H₂S生物学效应的认识发生了改变。本综述探讨了人们对H₂S作为哺乳动物内源性信号分子的认识不断增加的情况，重点关注其在泌尿系统中的生理和病理途径。本文综述了泌尿系统中与内源性H₂S相关的基础和药理学研究的最新进展，包括H₂S在抗氧化、炎症、细胞基质重塑和离子通道过程中的调节作用，以及内源性H₂S途径在肾脏和泌尿生殖系统疾病发病机制中的作用。
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