Massachusetts General Hospital, Department of Psychiatry, USA ; Harvard Medical School, USA ; Athinoula A. Martinos Center, USA ; McGovern Institute for Brain Research, Massachusetts Institute of Technology, USA.
Yale University School of Medicine, Department of Psychiatry, USA.
Neuroimage Clin. 2014 Jul 10;5:245-55. doi: 10.1016/j.nicl.2014.07.002. eCollection 2014.
While reducing the burden of brain disorders remains a top priority of organizations like the World Health Organization and National Institutes of Health, the development of novel, safe and effective treatments for brain disorders has been slow. In this paper, we describe the state of the science for an emerging technology, real time functional magnetic resonance imaging (rtfMRI) neurofeedback, in clinical neurotherapeutics. We review the scientific potential of rtfMRI and outline research strategies to optimize the development and application of rtfMRI neurofeedback as a next generation therapeutic tool. We propose that rtfMRI can be used to address a broad range of clinical problems by improving our understanding of brain-behavior relationships in order to develop more specific and effective interventions for individuals with brain disorders. We focus on the use of rtfMRI neurofeedback as a clinical neurotherapeutic tool to drive plasticity in brain function, cognition, and behavior. Our overall goal is for rtfMRI to advance personalized assessment and intervention approaches to enhance resilience and reduce morbidity by correcting maladaptive patterns of brain function in those with brain disorders.
虽然减轻脑部疾病的负担仍然是世界卫生组织和美国国立卫生研究院等组织的首要任务，但新型、安全和有效的脑部疾病治疗方法的发展一直较为缓慢。在本文中，我们描述了一种新兴技术实时功能磁共振成像（rtfMRI）神经反馈在临床神经治疗学中的科学现状。我们回顾了 rtfMRI 的科学潜力，并概述了研究策略，以优化 rtfMRI 神经反馈作为下一代治疗工具的开发和应用。我们提出，通过改善我们对大脑-行为关系的理解，rtfMRI 可以用于解决广泛的临床问题，从而为大脑疾病患者开发更具针对性和更有效的干预措施。我们专注于使用 rtfMRI 神经反馈作为临床神经治疗工具来驱动大脑功能、认知和行为的可塑性。我们的总体目标是通过纠正大脑疾病患者大脑功能的适应不良模式，使 rtfMRI 推进个性化评估和干预方法，以增强适应能力并降低发病率。
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