Department Clinical & Experimental Medicine, Division of Cell Biology, and Integrative Regenerative Medical Center, Linköping University, Linköping, Sweden; Instituto de Biologia Molecular y Biotecnologia, La Paz, Bolivia.
Department of Pathology, Pomeranian Medical University, Szczecin, Poland.
Trends Mol Med. 2014 Sep;20(9):519-28. doi: 10.1016/j.molmed.2014.07.003. Epub 2014 Aug 19.
Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have recently been found that also harbor apoptin-like proteins. Although the cancer cell specific activity of these apoptins appears to be well conserved, the precise functions and mechanisms of action are yet to be fully elucidated. Strategies for both delivering apoptin to treat tumors and disseminating the protein inside the tumor body are now being developed, and have shown promise in preclinical animal studies.
最近，选择性针对癌细胞进行杀伤的治疗方法一直是研究的重点。一种潜在的治疗方法可能涉及凋亡蛋白，它能够诱导癌细胞凋亡而不伤害正常细胞。凋亡蛋白最初是在鸡贫血病毒（CAV）中发现的；然而，最近发现人类回转病毒（HGyV）也含有类似凋亡蛋白的物质。尽管这些凋亡蛋白对癌细胞的特异性活性似乎得到了很好的保留，但它们的确切功能和作用机制仍有待充分阐明。目前正在开发将凋亡蛋白递送至肿瘤部位进行治疗和在肿瘤体内传播该蛋白的策略，并在临床前动物研究中显示出了希望。
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