视网膜视锥双极细胞的程序性细胞死亡独立于传入或靶标控制。
Programmed cell death of retinal cone bipolar cells is independent of afferent or target control.
作者信息
Keeley Patrick W, Madsen Nils R, St John Ace J, Reese Benjamin E
机构信息
Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106-5060, USA.
Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106-5060, USA; Department of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, CA 93106-9660, USA.
出版信息
Dev Biol. 2014 Oct 15;394(2):191-6. doi: 10.1016/j.ydbio.2014.08.018. Epub 2014 Aug 26.
Programmed cell death contributes to the histogenesis of the nervous system, and is believed to be modulated through the sustaining effects of afferents and targets during the period of synaptogenesis. Cone bipolar cells undergo programmed cell death during development, and we confirm that the numbers of three different types are increased when the pro-apoptotic Bax gene is knocked out. When their cone afferents are selectively eliminated, or when the population of retinal ganglion cells is increased, however, cone bipolar cell number remains unchanged. Programmed cell death of the cone bipolar cell populations, therefore, may be modulated cell-intrinsically rather than via interactions with these synaptic partners.
程序性细胞死亡有助于神经系统的组织发生，并且被认为在突触发生期间通过传入神经和靶标的持续作用进行调节。视锥双极细胞在发育过程中经历程序性细胞死亡，并且我们证实，当促凋亡的Bax基因被敲除时，三种不同类型的视锥双极细胞数量增加。然而，当它们的视锥传入神经被选择性消除，或者视网膜神经节细胞数量增加时，视锥双极细胞数量保持不变。因此，视锥双极细胞群体的程序性细胞死亡可能是由细胞内在调节的，而不是通过与这些突触伙伴的相互作用来调节。
Zotero 插件