ABCB1免疫组化表达与胃癌患者总生存期之间的关联。
Association between ABCB1 immunohistochemical expression and overall survival in gastric cancer patients.
作者信息
de Oliveira Juliana, Felipe Aledson Vitor, Neto Ricardo Artigiani, Oshima Celina Tizuko, de Souza Silva Marcelo, Forones Nora Manoukian
机构信息
Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, UNIFESP, SP, Brazil E-mail :
出版信息
Asian Pac J Cancer Prev. 2014;15(16):6935-8. doi: 10.7314/apjcp.2014.15.16.6935.
Gastric cancer (GC) is one of the most common malignancies worldwide. The ABCB1 protein, a member of the ATP-binding cassette (ABC) transporter family, encoded by the ABCB1 gene, considerably influences the distribution of drugs across cell membranes as well as multidrug resistance (MDR) of antineoplastic drugs. In contrast to the extensive knowledge on the pharmacological action of ABCB1 protein, the correlation between the clinical-pathological data and ABCB1 protein expression in patients with GC remains unclear. The aim was to investigate association between ABCB1 expression and overall survival in GC patients. Human tumor fragments from 57 GC patients were examined by immunohistochemistry assay. We observed lower survival rate of patients with GC who were positive for ABCB1 expression (p=0.030). Based on these observations, we conclude that GC patients with positive ABCB1 protein immunohistochemical expression in their tumors suffer shorter overall survival.
胃癌（GC）是全球最常见的恶性肿瘤之一。ABCB1蛋白是ATP结合盒（ABC）转运蛋白家族的成员，由ABCB1基因编码，它对药物跨细胞膜的分布以及抗肿瘤药物的多药耐药性（MDR）有很大影响。与对ABCB1蛋白药理作用的广泛了解形成对比的是，GC患者的临床病理数据与ABCB1蛋白表达之间的相关性仍不清楚。目的是研究ABCB1表达与GC患者总生存期之间的关联。通过免疫组织化学分析对57例GC患者的人肿瘤组织切片进行了检测。我们观察到ABCB1表达呈阳性的GC患者生存率较低（p = 0.030）。基于这些观察结果，我们得出结论，肿瘤中ABCB1蛋白免疫组化表达呈阳性的GC患者总生存期较短。
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