家族性混合性高脂血症中极低密度脂蛋白组成及含载脂蛋白B颗粒的决定因素。

Determinants of VLDL composition and apo B-containing particles in familial combined hyperlipidemia.

作者信息

Cruz-Bautista Ivette, Mehta Roopa, Cabiedes Javier, García-Ulloa Cristina, Guillen-Pineda Luz Elizabeth, Almeda-Valdés Paloma, Cuevas-Ramos Daniel, Aguilar-Salinas Carlos A

机构信息

Endocrinology and Metabolism Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Sección XVI, Tlalpan, 14000 Mexico City, Mexico.

Immunology and Rheumatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Sección XVI, Tlalpan, 14000 Mexico City, Mexico.

出版信息

Clin Chim Acta. 2015 Jan 1;438:160-5. doi: 10.1016/j.cca.2014.08.018. Epub 2014 Aug 27.

DOI:10.1016/j.cca.2014.08.018

PMID:25172037

Abstract

BACKGROUND

In familial combined hyperlipidemia (FCHL) the severity of the dyslipidemia is determined by an overproduction of VLDL (very low density lipoprotein) particles and by its abnormal lipid composition. However, few are known regarding the metabolic factors that determine these abnormalities. We investigated the impact of metabolic factors on the number of atherogenic particles (apolipoprotein B level (apoB)) and the triglyceride content of very low-density lipoproteins (VLDLs-TG).

METHODS

A cross-sectional study done in FCHL subjects and gender and age-matched healthy subjects. A clinical assessment, lipid profile and plasma concentrations of insulin, apolipoprotein CIII (apo CIII), apolipoprotein AII (apo AII), high sensitive C-reactive protein (HS-CRP), adiponectin and leptin were documented in 147 FCHL patients and 147 age-matched healthy subjects. Multivariate regression models were performed to investigate the independent determinants of VLDL-TG and apo B levels adjusting for confounding factors.

RESULTS

The variables that determined the VLDL-triglyceride content as a surrogate of VLDL composition were apo CIII (β=0.365, p<0.001), insulin (β=0.281, p<0.001), Apo AII (β=0.145, p<0.035), and adiponectin levels (β=-0.255, p<0.001). This model explained 34% of VLDL composition (VLDL-TG) variability. However, none of these variables were independent contributors of apo B-containing particles.

CONCLUSIONS

In patients with FCHL apo CIII, apo AII and adiponectin are major novel factors determining the VLDL particle composition. However, such factors do not explain apo B-containing particles.

摘要

背景

在家族性混合性高脂血症（FCHL）中，血脂异常的严重程度由极低密度脂蛋白（VLDL）颗粒的过量产生及其异常的脂质组成决定。然而，关于决定这些异常的代谢因素却知之甚少。我们研究了代谢因素对致动脉粥样硬化颗粒数量（载脂蛋白B水平（apoB））和极低密度脂蛋白甘油三酯含量（VLDL-TG）的影响。

方法

对FCHL患者以及性别和年龄匹配的健康受试者进行横断面研究。记录了147例FCHL患者和147例年龄匹配的健康受试者的临床评估、血脂谱以及胰岛素、载脂蛋白CIII（apo CIII）、载脂蛋白AII（apo AII）、高敏C反应蛋白（HS-CRP）、脂联素和瘦素的血浆浓度。进行多变量回归模型以研究调整混杂因素后VLDL-TG和apo B水平的独立决定因素。

结果

决定VLDL甘油三酯含量作为VLDL组成替代指标的变量是apo CIII（β=0.365，p<0.001）、胰岛素（β=0.281，p<0.001）、Apo AII（β=0.145，p<0.035）和脂联素水平（β=-0.255，p<0.001）。该模型解释了VLDL组成（VLDL-TG）变异性的34%。然而，这些变量均不是含apo B颗粒的独立影响因素。