单侧肾切除对雄性自发性糖尿病Torii肥胖大鼠肾功能的影响：一种新型肥胖2型糖尿病模型

Effects of unilateral nephrectomy on renal function in male Spontaneously Diabetic Torii fatty rats: a novel obese type 2 diabetic model.

作者信息

Katsuda Yoshiaki, Kemmochi Yusuke, Maki Mimi, Sano Ryuhei, Toriniwa Yasufumi, Ishii Yukihito, Miyajima Katsuhiro, Kakimoto Kochi, Ohta Takeshi

机构信息

Japan Tobacco Inc., Central Pharmaceutical Research Institute, Biological/Pharmacological Research Laboratories, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.

Japan Tobacco Inc., Central Pharmaceutical Research Institute, Toxicology Research Laboratories, 23 Naganuki, Hadano, Kanagawa 257-0024, Japan.

出版信息

J Diabetes Res. 2014;2014:363126. doi: 10.1155/2014/363126. Epub 2014 Aug 10.

DOI:10.1155/2014/363126

PMID:25177706

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4142530/

Abstract

The Spontaneously Diabetic Torii (SDT) fatty rat is a new model for obese type 2 diabetes. The aim of the present study was to investigate the effect of 1/2 nephrectomy (Nx) on renal function and morphology and on blood pressure in SDT fatty rats. Male SDT fatty rats underwent 1/2 Nx or a sham operation (Sham). Subsequently, animals were studied with respect to renal function and histological alterations. Induction of 1/2 Nx in SDT fatty rats led to functional and morphological damage to the remnant kidney and to hypertension, which are considered main characteristics of chronic kidney disease, at a younger age compared with the sham group. In conclusion, the SDT fatty rat is useful in investigations to elucidate the pathogenesis of human diabetic nephropathy and in new drug discovery.

摘要

自发性糖尿病Torii（SDT）肥胖大鼠是一种肥胖型2型糖尿病的新模型。本研究的目的是探讨1/2肾切除术（Nx）对SDT肥胖大鼠肾功能、形态及血压的影响。雄性SDT肥胖大鼠接受1/2 Nx或假手术（Sham）。随后，对动物的肾功能和组织学改变进行了研究。与假手术组相比，SDT肥胖大鼠诱导1/2 Nx导致残余肾的功能和形态损伤以及高血压，这些被认为是慢性肾病的主要特征，且发病年龄更小。总之，SDT肥胖大鼠有助于阐明人类糖尿病肾病的发病机制及新药研发。