通过碳-碳键断裂的酸催化酰化反应：一种合成3-酰基吲哚的简便且有明确机理的方法。
Acid-catalyzed acylation reaction via C-C bond cleavage: a facile and mechanistically defined approach to synthesize 3-acylindoles.
作者信息
Xing Qi, Li Pan, Lv Hui, Lang Rui, Xia Chungu, Li Fuwei
机构信息
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
出版信息
Chem Commun (Camb). 2014 Oct 18;50(81):12181-4. doi: 10.1039/c4cc05047a.
PMID:25177754
Abstract
A facile acid-catalyzed acylation of indoles with 1,3-dione as an eco-friendly acylating agent was developed. This protocol combines C-C bond cleavage and heterocyclic C-H bond functionalization to form new C-C bonds. Based on the detailed mechanistic studies, a credible mechanistic pathway was proposed.
摘要
开发了一种简便的以1,3 - 二酮作为环境友好型酰化剂的吲哚酸催化酰化反应。该方法结合了碳 - 碳键断裂和杂环碳 - 氢键官能团化以形成新的碳 - 碳键。基于详细的机理研究，提出了一条可靠的反应机理途径。
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