银杏叶提取物与盐酸米诺环素对牙周炎治疗效果的比较

Cheng Qian, Gao Weimin, Cao Bin, Liu Yingmei, Zeng Zuping, Wang Zuomin

Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.

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Zhonghua Kou Qiang Yi Xue Za Zhi. 2014 Jun;49(6):347-51.

OBJECTIVE

To compare the clinical effect of Ginkgo biloba extract gel (Ginkgo biloba extract,EGB) and minocycline hydrochloride (Periocline) on periodontitis and their inhibition on putative periodontal pathogens.

METHODS

Thirty patients with moderate-to-severe periodontitis were selected. The patients were divided into an experimental group and a positive control group (minocycline hydrochloride). Supragingival and subgingival scaling were performed on all patients. Subgingival plaque samples were collected before treatment, 1 week, 2 months and 4 months after treatment. The four major periodontal pathogens Porphyromonas gingivalis (Pg), Bacteroides forsythus (Bf), Prevotella intermedia (Pi), Treponema denticola (Td) were detected by polymerase chain reaction. Clinical indexes plaque index (PLI), bleeding index (BI) and probing depth (PD), attachment loss (AL) were examined before treatment, 3 months and 6 months after treatment. The results were statistically analyzed.

RESULTS

The detection rates of the 4 periodontal pathogens were Td (83.3%), Tf (95.0%), Pi (80.0%), Pg (81.7% ) in experimental group and Td (83.3%), Tf (95.0%), Pi (80.0%), Pg (81.7%) in control group before treatment. The detection rates in experimental group were not significantly different with those in control group after treatment, except for the detection rate of Pg 1 week after treatment (P < 0.01, the detection of Pg was 56.7% in experimental group and 53.3% in control group 1 week after treatment). The PLI and BI were not significantly different between experimental group and control group after treatment (P > 0.05). The difference was statistically significant at 6 months after treatment [(3.5 ± 0.5) mm for experimental group and (3.2 ± 0.4) mm for control group, P = 0.00]. The mean of AL decreased with time. The difference was statistically significant at 6 months after treatment [ (4.5 ± 0.4) mm for experimental group and (4.3 ± 0.4) mm for control group at 6 months, P = 0.01].

CONCLUSIONS

The inhibition effects of EGB and minocycline hydrochloride were comparable for major periodontal pathogens within short term.

目的

比较银杏叶提取物凝胶（银杏叶提取物，EGB）和盐酸米诺环素（派丽奥）治疗牙周炎的临床效果及其对牙周可疑致病菌的抑制作用。

方法

选取30例中重度牙周炎患者，分为试验组和阳性对照组（盐酸米诺环素）。所有患者均进行龈上洁治和龈下刮治。在治疗前、治疗后1周、2个月和4个月采集龈下菌斑样本。采用聚合酶链反应检测4种主要牙周致病菌牙龈卟啉单胞菌（Pg）、福赛坦氏菌（Bf）、中间普氏菌（Pi）、具核梭杆菌（Td）。在治疗前、治疗后3个月和6个月检查临床指标菌斑指数（PLI）、出血指数（BI）、探诊深度（PD）、附着丧失（AL），并对结果进行统计学分析。

结果

治疗前试验组4种牙周致病菌的检出率分别为Td（83.3%）、Tf（95.0%）、Pi（80.0%）、Pg（81.7%），对照组分别为Td（83.3%）、Tf（95.0%）、Pi（80.0%）、Pg（81.7%）。治疗后试验组与对照组的检出率比较，差异无统计学意义，仅治疗后1周Pg的检出率差异有统计学意义（P＜0.01，治疗后1周试验组Pg检出率为56.7%，对照组为53.3%）。治疗后试验组与对照组的PLI和BI比较，差异无统计学意义（P＞0.05）。治疗后6个月差异有统计学意义[试验组为（3.5±0.5）mm，对照组为（3.2±0.4）mm，P = 0.00]。AL均值随时间下降，治疗后6个月差异有统计学意义[试验组6个月时为（4.5±0.4）mm，对照组为（4.3±0.4）mm，P = 0.01]。