Psychological Counseling Center, Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, Henan Province, China.
Department of Clinical Psychology, Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, Henan Province, China.
Neural Regen Res. 2013 Oct 5;8(28):2666-76. doi: 10.3969/j.issn.1673-5374.2013.28.009.
This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders.
Online literature retrieval was conducted using PubMed, ISI Web of Science, EMBASE, Medline and Cochrane Central Register of Controlled Trials databases from January 1985 to May 2012. Key words were "transcranial magnetic stimulation", "TMS", "repetitive transcranial magnetic stimulation", and "hallucination".
Selected studies were randomized controlled trials assessing therapeutic efficacy of repetitive transcranial magnetic stimulation for hallucination in patients with schizophrenia spectrum disorders. Experimental intervention was low-frequency repetitive transcranial magnetic stimulation in left temporoparietal cortex for treatment of auditory hallucination in schizophrenia spectrum disorders. Control groups received sham stimulation.
The primary outcome was total scores of Auditory Hallucinations Rating Scale, Auditory Hallucination Subscale of Psychotic Symptom Rating Scale, Positive and Negative Symptom Scale-Auditory Hallucination item, and Hallucination Change Scale. Secondary outcomes included response rate, global mental state, adverse effects and cognitive function.
Seventeen studies addressing repetitive transcranial magnetic stimulation for treatment of schizophrenia spectrum disorders were screened, with controls receiving sham stimulation. All data were completely effective, involving 398 patients. Overall mean weighted effect size for repetitive transcranial magnetic stimulation versus sham stimulation was statistically significant (MD = -0.42, 95%CI: -0.64 to -0.20, P = 0.000 2). Patients receiving repetitive transcranial magnetic stimulation responded more frequently than sham stimulation (OR = 2.94, 95%CI: 1.39 to 6.24, P = 0.005). No significant differences were found between active repetitive transcranial magnetic stimulation and sham stimulation for positive or negative symptoms. Compared with sham stimulation, active repetitive transcranial magnetic stimulation had equivocal outcome in cognitive function and commonly caused headache and facial muscle twitching.
Repetitive transcranial magnetic stimulation is a safe and effective treatment for auditory hallucination in schizophrenia spectrum disorders.
本研究评估了重复经颅磁刺激治疗精神分裂症谱系障碍患者幻听的疗效和耐受性。
在线检索 PubMed、ISI Web of Science、EMBASE、Medline 和 Cochrane 对照试验中心注册数据库，检索时间从 1985 年 1 月至 2012 年 5 月，检索词为“transcranial magnetic stimulation”“TMS”“repetitive transcranial magnetic stimulation”和“hallucination”。
入选研究为评估重复经颅磁刺激治疗精神分裂症谱系障碍患者幻听疗效的随机对照试验。实验干预为低频重复经颅磁刺激左颞顶叶皮质治疗精神分裂症谱系障碍的幻听。对照组接受假刺激。
主要结局指标为听觉幻觉评定量表总分、精神病症状评定量表听觉幻觉亚量表、阳性和阴性症状量表-听觉幻觉条目、幻觉变化量表。次要结局指标包括反应率、总体精神状态、不良反应和认知功能。
筛选出 17 项关于重复经颅磁刺激治疗精神分裂症谱系障碍的研究，对照组接受假刺激。所有数据均完全有效，共涉及 398 例患者。重复经颅磁刺激与假刺激相比，总体平均加权效应量具有统计学意义（MD=-0.42，95%CI：-0.64 至-0.20，P=0.0002）。接受重复经颅磁刺激治疗的患者比接受假刺激治疗的患者更频繁地出现反应（OR=2.94，95%CI：1.39 至 6.24，P=0.005）。与假刺激相比，活跃的重复经颅磁刺激在阳性或阴性症状方面没有显著差异。与假刺激相比，活跃的重复经颅磁刺激对认知功能的效果不确定，且通常会引起头痛和面部肌肉抽搐。
重复经颅磁刺激是治疗精神分裂症谱系障碍患者幻听的一种安全有效的方法。
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