Department of Geriatrics, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
Department of Neurology, Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
Neural Regen Res. 2014 Feb 1;9(3):268-75. doi: 10.4103/1673-5374.128220.
In addition to its lipid-lowering effect, atorvastatin exerts anti-inflammatory and antioxidant effects as well. In this study, we hypothesized that atorvastatin could protect against cerebral ischemia/reperfusion injury. The middle cerebral artery ischemia/reperfusion model was established, and atorvastatin, 6.5 mg/kg, was administered by gavage. We found that, after cerebral ischemia/reperfusion injury, levels of the inflammation-related factors E-selectin and myeloperoxidase were upregulated, the oxidative stress-related marker malondialdehyde was increased, and superoxide dismutase activity was decreased in the ischemic cerebral cortex. Atorvastatin pretreatment significantly inhibited these changes. Our findings indicate that atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects.
除了降低血脂的作用外，阿托伐他汀还具有抗炎和抗氧化作用。在本研究中，我们假设阿托伐他汀可以预防脑缺血/再灌注损伤。建立大脑中动脉缺血/再灌注模型，灌胃给予阿托伐他汀 6.5mg/kg。我们发现，脑缺血/再灌注损伤后，炎症相关因子 E-选择素和髓过氧化物酶水平上调，氧化应激相关标志物丙二醛增加，缺血大脑皮质中超氧化物歧化酶活性降低。阿托伐他汀预处理可显著抑制这些变化。我们的研究结果表明，阿托伐他汀通过抗炎和抗氧化作用来保护大脑免受缺血/再灌注损伤。
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