VII型胶原是致密板下型线状IgA大疱性皮肤病的主要自身抗原。 - Suppr

Type VII collagen is the major autoantigen for sublamina densa-type linear IgA bullous dermatosis.

作者信息

Tsuchisaka Atsunari, Ohara Koji, Ishii Norito, Nguyen Ngon T, Marinkovich M Peter, Hashimoto Takashi

机构信息

Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Fukuoka, Japan.

Department of Dermatology, Stanford University School of Medicine, Center for Clinical Sciences Research, Stanford, California, USA.

出版信息

J Invest Dermatol. 2015 Feb;135(2):626-629. doi: 10.1038/jid.2014.381. Epub 2014 Sep 10.

DOI:10.1038/jid.2014.381

PMID:25207819

Abstract

摘要

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Type VII collagen is the major autoantigen for sublamina densa-type linear IgA bullous dermatosis.

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Epidermolysis bullosa acquisita sera react with distinct epitopes on the NC1 and NC2 domains of type VII collagen: study using immunoblotting of domain-specific recombinant proteins and postembedding immunoelectron microscopy.

Br J Dermatol. 2004 May;150(5):843-51. doi: 10.1111/j.1365-2133.2004.05933.x.

Immunofluorescence studies using skin sections of recessive dystrophic epidermolysis bullosa patients indicated that the antigen of anti-p200 pemphigoid is not a fragment of type VII collagen.

J Dermatol Sci. 2003 Aug;32(2):125-9. doi: 10.1016/s0923-1811(03)00092-6.

Linear IgA bullous dermatosis.

Clin Dermatol. 2001 Nov-Dec;19(6):719-27. doi: 10.1016/s0738-081x(00)00185-1.

A case of linear IgA bullous dermatosis with IgA anti-type VII collagen autoantibodies.

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J Clin Invest. 1990 Mar;85(3):812-20. doi: 10.1172/JCI114508.

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Type VII collagen is the major autoantigen for sublamina densa-type linear IgA bullous dermatosis.

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