Dinescu Sorina, Ionita Mariana, Pandele Andreea Madalina, Galateanu Bianca, Iovu Horia, Ardelean Aurel, Costache Marieta, Hermenean Anca
Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.
University Politehnica of Bucharest, Calea Victoriei 149, 010072 Bucharest, Romania.
Biomed Mater Eng. 2014;24(6):2249-56. doi: 10.3233/BME-141037.
Extensively studied nowadays, graphene oxide (GO) has a benefic effect on cell proliferation and differentiation, thus holding promise for bone tissue engineering (BTE) approaches. The aim of this study was not only to design a chitosan 3D scaffold improved with GO for optimal BTE, but also to analyze its physicochemical properties and to evaluate its cytocompatibility and ability to support cell metabolic activity and proliferation. Overall results show that the addition of GO in the scaffold's composition improved mechanical properties and pore formation and enhanced the bioactivity of the scaffold material for tissue engineering. The new developed CHT/GO 3 wt% scaffold could be a potential candidate for further in vitro and in vivo osteogenesis studies and BTE approaches.
如今，氧化石墨烯（GO）得到了广泛研究，它对细胞增殖和分化具有有益作用，因此在骨组织工程（BTE）方法中具有应用前景。本研究的目的不仅是设计一种用GO改良的壳聚糖三维支架以实现最佳的骨组织工程，还要分析其物理化学性质，并评估其细胞相容性以及支持细胞代谢活性和增殖的能力。总体结果表明，在支架成分中添加GO改善了机械性能和孔隙形成，并增强了用于组织工程的支架材料的生物活性。新开发的含3 wt% GO的壳聚糖支架可能是进一步进行体外和体内成骨研究以及骨组织工程方法的潜在候选材料。
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