类Sec14磷脂酰肌醇转移蛋白与磷酸肌醇信号转导结果的多样化
Sec14-like phosphatidylinositol-transfer proteins and diversification of phosphoinositide signalling outcomes.
作者信息
Tripathi Ashutosh, Nile Aaron H, Bankaitis Vytas A
机构信息
*Department of Molecular & Cellular Medicine, Texas A&M Health Science Center, College Station, TX 77843-1114, U.S.A.
出版信息
Biochem Soc Trans. 2014 Oct;42(5):1383-8. doi: 10.1042/BST20140187.
Abstract
The physiological functions of phosphatidylinositol (PtdIns)-transfer proteins (PITPs)/phosphatidylcholine (PtdCho)-transfer proteins are poorly characterized, even though these proteins are conserved throughout the eukaryotic kingdom. Much of the progress in elucidating PITP functions has come from exploitation of genetically tractable model organisms, but the mechanisms for how PITPs execute their biological activities remain unclear. Structural and molecular dynamics approaches are filling in the details for how these proteins actually work as molecules. In the present paper, we discuss our recent work with Sec14-like PITPs and describe how PITPs integrate diverse territories of the lipid metabolome with phosphoinositide signalling.
摘要
磷脂酰肌醇（PtdIns）转运蛋白（PITPs）/磷脂酰胆碱（PtdCho）转运蛋白的生理功能尚未得到充分表征，尽管这些蛋白在整个真核生物界都是保守的。在阐明PITP功能方面取得的许多进展都来自对易于进行基因操作的模式生物的研究，但PITP如何执行其生物学活性的机制仍不清楚。结构和分子动力学方法正在填补这些蛋白作为分子实际发挥作用方式的细节。在本文中，我们讨论了我们最近对Sec14样PITP的研究工作，并描述了PITP如何将脂质代谢组的不同区域与磷酸肌醇信号传导整合起来。
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