School of Materials Science & Engineering, College of Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
Sorbonne Universités, UPMC, Univ Paris 6, UMR CNRS 7197, Laboratoire de Réactivité de Surface, F-75005 Paris, France; CNRS, UMR 7197, Laboratoire de Réactivité de Surface, F-75005 Paris, France.
Biosens Bioelectron. 2015 Feb 15;64:373-85. doi: 10.1016/j.bios.2014.08.090. Epub 2014 Sep 16.
Graphene and graphene-like two-dimensional nanomaterials have aroused tremendous research interest in recent years due to their unique electronic, optical, and mechanical properties associated with their planar structure. Aptamers have exhibited many advantages as molecular recognition elements for sensing devices compared to traditional antibodies. The marriage of two-dimensional nanomaterials and aptamers has emerged many ingenious aptasensing strategies for applications in the fields of clinical diagnosis and food safety. This review highlights current advances in the development and application of two-dimensional nanomaterials-based aptasensors with the focus on two main signal-transducing mechanisms, i.e. electrochemical and optical. A special attention is paid to graphene, a one-atom thick layer of graphite with exceptional properties, representing a fastgrowing field of research. In view of the unique properties of two-dimensional nanostructures and their inherent advantages of synthetic aptamers, we expect that high-performance two-dimensional nanomaterials-based aptasensing devices will find extensive applications in environmental monitoring, biomedical diagnostics, and food safety.
近年来，由于其平面结构所带来的独特的电子、光学和机械性能，石墨烯和类石墨烯二维纳米材料引起了人们的极大研究兴趣。与传统抗体相比，适体作为分子识别元件在传感设备中表现出许多优势。二维纳米材料和适体的结合为临床诊断和食品安全等领域的应用带来了许多巧妙的适体传感策略。本综述重点介绍了基于二维纳米材料的适体传感器的最新发展和应用，主要关注两种主要的信号转导机制，即电化学和光学。特别关注具有特殊性质的单层石墨——石墨烯，这是一个快速发展的研究领域。鉴于二维纳米结构的独特性质和合成适体的固有优势，我们预计基于二维纳米材料的高性能适体传感设备将在环境监测、生物医学诊断和食品安全等领域得到广泛应用。
