18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描在宫颈癌患者术前评估中的有效性：一项回顾性病理匹配研究

Validity of 18F-fluorodeoxyglucose positron emission tomography/computed tomography for pretreatment evaluation of patients with cervical carcinoma: a retrospective pathology-matched study.

作者信息

Dong Yu, Wang Xiaoyun, Wang Yanan, Liu Yuan, Zhang Jiawen, Qian Wenyan, Wu Sufang

机构信息

*Department of Obstetrics and Gynecology, Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China; †Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Shanghai, China; and ‡Department of Obstetrics and Gynecology, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, China.

出版信息

Int J Gynecol Cancer. 2014 Nov;24(9):1642-7. doi: 10.1097/IGC.0000000000000287.

DOI:10.1097/IGC.0000000000000287

PMID:25268748

Abstract

OBJECTIVE

The aim of this study was to evaluate the validity of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) for pretreatment evaluation of patients with cervical carcinoma.

METHODS

Retrospective evaluation of 63 patients, diagnosed with stage IA-IIA cervical carcinoma who underwent 18F-FDG PET/CT before surgery, was performed. Sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratios (LRs) of PET/CT for predicting the positive cervix, vagina, uterine body, and lymph node invasion at the surgical specimen was calculated.

RESULTS

Sensitivity, specificity, positive predictive value, and negative predictive value of the positive cervix invasion in PET/CT to detect positive surgical specimen were 88.2%, 75%, 93.8%, and 60%, respectively. The LR+ ratio was 3.5, and the LR- ratio was 0.2. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive vagina invasion in PET/CT to detect positive surgical specimen were 100%, 70.97%, 5.3%, and 100%, respectively. The LR+ ratio was 3.4, and the LR- ratio was 0. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive uterine body invasion in PET/CT to detect positive surgical specimen were 75%, 83.1%, 23.1%, and 98%, respectively. The LR+ ratio was 4.4, and the LR- ratio was 0.3. Sensitivity, specificity, positive predictive value, and negative predictive value of the positive lymph node invasion in PET/CT to detect positive surgical specimen were 87.5%, 78.4%, 38.9%, and 97.6%, respectively. The LR+ ratio was 4.1, and the LR- ratio was 0.2.

CONCLUSIONS

The cervix invasion, negative uterine body invasion, and negative lymph node invasion are effective 18F-FDG PET/CT findings.

摘要

目的

本研究旨在评估18F-氟脱氧葡萄糖（18F-FDG）正电子发射断层扫描（PET）/计算机断层扫描（CT）在宫颈癌患者术前评估中的有效性。

方法

对63例诊断为IA-IIA期宫颈癌且术前接受18F-FDG PET/CT检查的患者进行回顾性评估。计算PET/CT预测手术标本中宫颈、阴道、子宫体和淋巴结转移阳性的敏感性、特异性、阳性预测值、阴性预测值及似然比（LRs）。

结果

PET/CT检测手术标本中宫颈转移阳性的敏感性、特异性、阳性预测值和阴性预测值分别为88.2%、75%、93.8%和60%。阳性似然比为3.5，阴性似然比为0.2。PET/CT检测手术标本中阴道转移阳性的敏感性、特异性、阳性预测值和阴性预测值分别为100%、70.97%、5.3%和100%。阳性似然比为3.4，阴性似然比为0。PET/CT检测手术标本中子宫体转移阳性的敏感性、特异性、阳性预测值和阴性预测值分别为75%、83.1%、23.1%和98%。阳性似然比为4.4，阴性似然比为0.3。PET/CT检测手术标本中淋巴结转移阳性的敏感性、特异性、阳性预测值和阴性预测值分别为87.5%、78.4%、38.9%和97.6%。阳性似然比为4.1，阴性似然比为0.2。