急性血管紧张素转换酶抑制对心房利钠肽的影响。
The effect of acute ACE inhibition on atrial natriuretic peptide.
作者信息
Doorenbos C J, van Brummelen P
机构信息
Department of Nephrology, University Hospital, Leiden, The Netherlands.
出版信息
Br J Clin Pharmacol. 1989;27 Suppl 2(Suppl 2):243S-247S. doi: 10.1111/j.1365-2125.1989.tb03488.x.
Abstract
- The effect of acute angiotensin converting enzyme (ACE) inhibition on the plasma concentrations of atrial natriuretic peptide (ANP) was investigated in a single-blind placebo controlled crossover study in healthy volunteers. 2. Intravenous infusion of 2 mg cilazaprilat resulted in a significant and short lasting inhibition of ACE as evidenced by a decrease of plasma angiotensin II and an increase in plasma renin activity. 3. When compared with placebo cilazaprilat lowered diastolic pressure and increased heart rate significantly. 4. No effect of cilazaprilat was found on plasma ANP levels, suggesting that angiotensin II does not mediate ANP release.
摘要
- 在一项针对健康志愿者的单盲安慰剂对照交叉研究中，研究了急性血管紧张素转换酶（ACE）抑制对血浆心房利钠肽（ANP）浓度的影响。2. 静脉输注2毫克西拉普利拉导致ACE受到显著且短暂的抑制，血浆血管紧张素II降低和血浆肾素活性增加证明了这一点。3. 与安慰剂相比，西拉普利拉显著降低舒张压并增加心率。4. 未发现西拉普利拉对血浆ANP水平有影响，这表明血管紧张素II不介导ANP的释放。
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