细胞外基质生物学：概述
Biology of the extracellular matrix: an overview.
作者信息
Yue Beatrice
机构信息
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, IL.
出版信息
J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S20-3. doi: 10.1097/IJG.0000000000000108.
Abstract
The extracellular matrix (ECM) is an intricate network composed of an array of multidomain macromolecules organized in a cell/tissue-specific manner. Components of the ECM link together to form a structurally stable composite, contributing to the mechanical properties of tissues. The ECM is also a reservoir of growth factors and bioactive molecules. It is a highly dynamic entity that is of vital importance, determining and controlling the most fundamental behaviors and characteristics of cells such as proliferation, adhesion, migration, polarity, differentiation, and apoptosis.
摘要
细胞外基质（ECM）是一个复杂的网络，由一系列以细胞/组织特异性方式组织的多结构域大分子组成。ECM的成分相互连接形成结构稳定的复合物，有助于组织的机械性能。ECM也是生长因子和生物活性分子的储存库。它是一个高度动态的实体，至关重要，决定和控制细胞的最基本行为和特征，如增殖、粘附、迁移、极性、分化和凋亡。
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