Jeong Hyerin, Sung Kyung Rim
Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Korean J Ophthalmol. 2014 Oct;28(5):393-8. doi: 10.3341/kjo.2014.28.5.393. Epub 2014 Sep 18.
To evaluate the clinical outcome of viscoelastics (VE, sodium hyaluronate)-augmented trabeculectomy (VAT, 66 eyes) and conventional trabeculectomy (CT, 57 eyes) for glaucomatous eyes.
In the VAT group, half of the anterior chamber space was filled with VE via the paracentesis site at the end of CT and a balanced salt solution was injected into the anterior chamber. This procedure induced migration of VE from the anterior chamber into the bleb space; thus the bleb was elevated with underlying VE. Follow-up examinations were performed until 1 year after surgery. Success was defined as the attainment of an intraocular pressure (IOP) greater than 5 mmHg and less than 22 mmHg. If IOP was in the range of success without antiglaucoma medication, it was regarded as a complete success.
The mean postoperative IOP was significantly lower in the VAT group at postoperative 1 day, 1 week, and 1 month. The complete success rate was significantly higher in the VAT group (89%) than in the CT group (75%), though the qualified success rate was not different between the two groups. The number of IOP-lowering medications at postoperative 1 year was significantly higher in the CT group (1.30 ± 1.08 vs. 0.73 ± 0.98, p = 0.003). Among postoperative procedures, laser suture lysis was required less frequently in the VAT group (p < 0.001).
Placing VE within the bleb at the end of surgery may result in better IOP control and less need for IOP-lowering medication without any additional materials, cost, or time.
评估黏弹剂(VE,透明质酸钠)辅助小梁切除术(VAT,66只眼)和传统小梁切除术(CT,57只眼)治疗青光眼的临床效果。
在VAT组中,在CT结束时通过穿刺部位向一半前房空间注入VE,并向前房注入平衡盐溶液。该操作促使VE从前房迁移至滤过泡间隙;因此滤过泡在下方VE的作用下隆起。术后随访至1年。成功定义为眼压(IOP)大于5 mmHg且小于22 mmHg。如果在未使用抗青光眼药物的情况下眼压处于成功范围内,则视为完全成功。
VAT组术后1天、1周和1个月时的平均术后眼压显著更低。VAT组的完全成功率(89%)显著高于CT组(75%),尽管两组的合格成功率无差异。CT组术后1年降低眼压药物的使用数量显著更多(1.30±1.08 vs. 0.73±0.98,p = 0.003)。在术后操作中,VAT组所需的激光缝线松解术频率更低(p < 0.001)。
手术结束时在滤过泡内放置VE可能在无需任何额外材料、成本或时间的情况下更好地控制眼压,且减少降低眼压药物的使用需求。