甲基强的松龙对体外培养的哺乳动物神经元网络的影响。
Effect of methylprednisolone on mammalian neuronal networks in vitro.
作者信息
Wittstock Matthias, Rommer Paulus S, Schiffmann Florian, Jügelt Konstantin, Stüwe Simone, Benecke Reiner, Schiffmann Dietmar, Zettl Uwe K
机构信息
Department of Neurology, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany,
出版信息
Cell Mol Neurobiol. 2015 Jan;35(1):111-4. doi: 10.1007/s10571-014-0117-y. Epub 2014 Oct 5.
Abstract
Glucocorticosteroids (GCS) are widely used for the treatment of neurological diseases, e.g. multiple sclerosis. High levels of GCS are toxic to the central nervous system and can produce adverse effects. The effect of methylprednisolone (MP) on mammalian neuronal networks was studied in vitro. We demonstrate a dose-dependent excitatory effect of MP on cultured neuronal networks, followed by a shut-down of electrical activity using the microelectrode array technique.
摘要
糖皮质激素（GCS）被广泛用于治疗神经系统疾病，如多发性硬化症。高剂量的GCS对中枢神经系统有毒性，并会产生不良反应。我们在体外研究了甲基强的松龙（MP）对哺乳动物神经元网络的影响。我们使用微电极阵列技术证明了MP对培养的神经元网络具有剂量依赖性兴奋作用，随后电活动停止。
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