意大利一个地区肌萎缩侧索硬化症（ALS）患者队列中的血铅、血锰和血铝水平：铝有影响吗？
Blood lead, manganese, and aluminum levels in a regional Italian cohort of ALS patients: does aluminum have an influence?
作者信息
Garzillo Elpidio Maria, Lamberti Monica, Genovese Giuliana, Pedata Paola, Feola Daniela, Sannolo Nicola, Daniele Luca, Trojsi Francesca, Monsurro Maria Rosaria, Miraglia Nadia
机构信息
From the Department of Experimental Medicine (Drs Garzillo, Lamberti, Genovese, Pedata, and Feola and Mr Sannolo and Mr Miraglia), Section of Hygiene, Occupational Medicine and Forensic Medicine, Occupational Medicine Area; and Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences (Dr Daniele, Dr Trojsi, and Dr Monsurro), Second University of Naples, Italy.
出版信息
J Occup Environ Med. 2014 Oct;56(10):1062-6. doi: 10.1097/JOM.0000000000000266.
OBJECTIVES
To study aluminum (Al), manganese (Mn), and lead (Pb) influence on amyotrophic lateral sclerosis (ALS) development.
METHODS
A total of 34 patients (10% of the regional ALS population) and 25 controls of an Italian region were enrolled. Metal concentrations were determined by atomic absorption spectroscopy.
RESULTS
Serum Al concentrations in patients and controls were similar and lower than those provided by the Italian Society of Reference Values. No differences were observed in serum Mn concentrations, while, as expected, blood Pb levels were significantly higher in patients with ALS than those in controls.
CONCLUSIONS
Results confirmed the association between high Pb blood levels and ALS; on the contrary, Al and Mn did not differ significantly in patients and controls, suggesting that Mn and especially Al may play a less important role in the ALS pathogenesis.
目的
研究铝（Al）、锰（Mn）和铅（Pb）对肌萎缩侧索硬化症（ALS）发展的影响。
方法
招募了意大利某地区的34名患者（占该地区ALS患者总数的10%）和25名对照者。通过原子吸收光谱法测定金属浓度。
结果
患者和对照者的血清铝浓度相似，且低于意大利参考值协会提供的浓度。血清锰浓度未观察到差异，而正如预期的那样，ALS患者的血铅水平显著高于对照者。
结论
结果证实了高血铅水平与ALS之间的关联；相反，患者和对照者的铝和锰没有显著差异，这表明锰尤其是铝在ALS发病机制中可能起的作用较小。
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