He Peng, Zheng Haifeng, Liu Xiaohua, Lian Xiangjin, Lin Lili, Feng Xiaoming
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (P. R. China), Fax: (+86) 28-8541-8249.
Chemistry. 2014 Oct 13;20(42). doi: 10.1002/chem.201484271.
Asymmetric Alkali Metal Borohydride Reduction Alkali metal borohydrides are mild, inexpensive, highly selective, and environmentally friendly reducing agents in organic chemistry. In their Communication on page 13482 ff., X. Feng et al. demonstrate an efficient enantioselective reduction of both secondary and primary α-amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts. The catalytic system features a convenient operation and tolerance to water, without the need for basic additives.
不对称碱金属硼氢化物还原反应 碱金属硼氢化物在有机化学中是温和、廉价、高选择性且环境友好的还原剂。在第13482页及以后的通讯文章中，冯X等人展示了在手性N,N'-二氧化物-金属络合物催化剂催化下，硼氢化钾溶液对仲α-氨基酮和伯α-氨基酮进行高效对映选择性还原反应。该催化体系操作简便且对水具有耐受性，无需碱性添加剂。
