基于人群的杜兴氏和贝克氏肌营养不良男性队列中的泌尿生殖系统健康状况。
Genitourinary health in a population-based cohort of males with Duchenne and Becker Muscular dystrophies.
作者信息
Zhu Yong, Romitti Paul A, Caspers Conway Kristin M, Kim Sunkyung, Zhang Ying, Yang Michele, Mathews Katherine D
机构信息
Department of Epidemiology, The University of Iowa, S416 CPHB, 145 North Riverside Drive, Iowa City, Iowa, 52242, USA.
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Muscle Nerve. 2015 Jul;52(1):22-7. doi: 10.1002/mus.24486. Epub 2015 Jun 3.
INTRODUCTION
Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data.
METHODS
Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early- vs. late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids).
RESULTS
Among the 918 males, 81 (9%) had a GU condition, with voiding dysfunction (n = 40), GU tract infection (n = 19), and kidney/ureter calculus (n = 9) most frequently seen. The Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR 2.7, 95% CI 1.3-5.6).
CONCLUSIONS
Our findings highlight the need for increased awareness of GU health and multidisciplinary care of DBMD patients.
引言
尚未利用基于人群的数据对杜氏和贝克肌营养不良症（DBMD）患者的泌尿生殖系统（GU）健康状况进行研究。
方法
对肌肉萎缩症监测、追踪和研究网络确定的918名男性的医疗记录进行审查，以记录与GU相关的住院情况和处方药物。计算接受这些医疗干预的男性百分比，并估计与社会人口统计学（研究地点、种族/民族）、症状（早发与晚发、行走状态、脊柱侧弯）和治疗（呼吸支持、类固醇）的关联的风险比（HR）和95%置信区间（CI）。
结果
在918名男性中，81名（9%）患有GU疾病，最常见的是排尿功能障碍（n = 40）、GU道感染（n = 19）和肾/输尿管结石（n = 9）。Kaplan-Meier曲线得出的累积概率为27%。Cox回归显示，非行走男性的GU疾病更为常见（HR 2.7，95% CI 1.3 - 5.6）。
结论
我们的研究结果强调了提高对DBMD患者GU健康的认识和多学科护理的必要性。
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