记忆改变测试可区分认知健康状态、轻度认知障碍和阿尔茨海默病。
The Memory Alteration Test Discriminates between Cognitively Healthy Status, Mild Cognitive Impairment and Alzheimer's Disease.
作者信息
Custodio Nilton, Lira David, Herrera-Perez Eder, Nuñez Del Prado Liza, Parodi José, Guevara-Silva Erik, Castro-Suarez Sheila, Montesinos Rosa, Cortijo Patricia
机构信息
Servicio de Neurología, Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Universidad Peruana Cayetano Heredia, Lima, Peru ; Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Universidad Peruana Cayetano Heredia, Lima, Peru ; Unidad de Investigación, Instituto Peruano de Neurociencias, Universidad Peruana Cayetano Heredia, Lima, Peru.
Unidad de Investigación, Instituto Peruano de Neurociencias, Universidad Peruana Cayetano Heredia, Lima, Peru ; Unidad de Diseño y Elaboración de Proyectos de Investigación, Universidad Peruana Cayetano Heredia, Lima, Peru ; Centro de Investigación para el Desarrollo Integral y Sostenible, Universidad Peruana Cayetano Heredia, Lima, Peru.
出版信息
Dement Geriatr Cogn Dis Extra. 2014 Aug 27;4(2):314-21. doi: 10.1159/000365280. eCollection 2014 May.
BACKGROUND/AIMS: Dementia is a worldwide public health problem and there are several diagnostic tools for its assessment. The aim of this study was to evaluate the performance of the Memory Alteration Test (M@T) to discriminate between patients with early Alzheimer's disease (AD), patients with amnestic mild cognitive impairment (a-MCI), and subjects with a cognitively healthy status (CHS).
METHODS
The discriminative validity was assessed in a sample of 90 patients with AD, 45 patients with a-MCI, and 180 subjects with CHS. Clinical, functional, and cognitive studies were independently performed in a blinded fashion and the gold standard diagnosis was established by consensus on the basis of these results. The test performance was assessed by means of a receiver operating characteristic curve analysis as area under the curve (AUC).
RESULTS
M@T mean scores were 17.7 (SD = 5.7) in AD, 30.8 (SD = 2.3) in a-MCI, and 44.5 (SD = 3.1) in CHS. A cutoff score of 37 points had a sensitivity of 98.3% and a specificity of 97.8% to differentiate a-MCI from CHS (AUC = 0.999). A cutoff score of 27 points had a sensitivity of 100% and a specificity of 98.9% to differentiate mild AD from a-MCI and from CHS (AUC = 1.000).
CONCLUSIONS
The M@T had a high performance in the discrimination between early AD, a-MCI and CHS.
背景/目的：痴呆是一个全球性的公共卫生问题，有多种用于评估的诊断工具。本研究的目的是评估记忆改变测试（M@T）在区分早期阿尔茨海默病（AD）患者、遗忘型轻度认知障碍（a-MCI）患者和认知健康状态（CHS）受试者方面的性能。
方法
在90例AD患者、45例a-MCI患者和180例CHS受试者的样本中评估判别效度。临床、功能和认知研究以盲法独立进行，并根据这些结果通过共识确定金标准诊断。通过受试者操作特征曲线分析评估测试性能，以曲线下面积（AUC）表示。
结果
AD患者的M@T平均得分为17.7（标准差=5.7），a-MCI患者为30.8（标准差=2.3），CHS受试者为44.5（标准差=3.1）。37分的截断分数区分a-MCI与CHS的灵敏度为98.3%，特异度为97.8%（AUC=0.999）。27分的截断分数区分轻度AD与a-MCI及CHS的灵敏度为100%，特异度为98.9%（AUC=1.000）。
结论
M@T在区分早期AD、a-MCI和CHS方面具有较高性能。
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