谷胱甘肽S-转移酶ω（GSTO）基因多态性与癌症风险：20项研究的荟萃分析
Genetic polymorphisms in Glutathione S-transferase Omega (GSTO) and cancer risk: a meta-analysis of 20 studies.
作者信息
Xu You-Tao, Wang Jun, Yin Rong, Qiu Man-Tang, Xu Lei, Wang Jie, Xu Lin
机构信息
1] Department of Thoracic Surgery, Nanjing Medical University affiliated cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Baiziting 42, Nanjing, P.R. China. 210009 [2] The First Clinical College of Nanjing Medical University, Nanjing. 210000, China [3].
1] Department of Hematology and Oncology, Jiangsu Province Geriatric Institute, No. 30 Luojia Road, Nanjing 210029, China [2].
出版信息
Sci Rep. 2014 Oct 10;4:6578. doi: 10.1038/srep06578.
Glutathione S-transferase Omega (GSTO) plays an important role in the development of cancer. Recently, a number of studies have investigated the association between single nucleotide polymorphisms on GSTO and susceptibility to cancer; however, the results remain inconclusive. We performed a meta-analysis of 20 studies, involving 4770 cases and 5701 controls to identify the strength of association by pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Overall, the pooled results revealed a significantly increased risk of susceptibility for GSTO2 polymorphism (GG vs. AA: OR = 1.20, 95%CI: 1.02-1.41, Pheterogeneity = 0.116), but no significant association was found for GSTO1 polymorphism. Subgroup analysis showed that GSTO2 polymorphism significantly increased cancer risk in Caucasian population (GG vs. AA: OR = 1.32, 95%CI 1.06-1.64, Pheterogeneity = 0.616) and GSTO2 polymorphism was significantly associated with elevated risk of breast cancer (GG vs. AA OR = 1.37, 95%CI: 1.06-1.77; Pheterogeneity = 0.281). This meta-analysis demonstrates that GSTO2 polymorphism may significantly increase cancer risk in Caucasian population and is associated with elevated risk of breast cancer; while GSTO1 polymorphism is not associated with cancer risk.
谷胱甘肽S-转移酶Omega（GSTO）在癌症发展中起重要作用。最近，一些研究调查了GSTO单核苷酸多态性与癌症易感性之间的关联；然而，结果仍无定论。我们对20项研究进行了荟萃分析，涉及4770例病例和5701例对照，通过合并比值比（OR）及相应的95%置信区间（CI）来确定关联强度。总体而言，汇总结果显示GSTO2多态性（GG与AA相比：OR = 1.20，95%CI：1.02 - 1.41，P异质性 = 0.116）的易感性风险显著增加，但未发现GSTO1多态性有显著关联。亚组分析表明，GSTO2多态性在白种人群中显著增加癌症风险（GG与AA相比：OR = 1.32，95%CI 1.06 - 1.64，P异质性 = 0.616），且GSTO2多态性与乳腺癌风险升高显著相关（GG与AA相比OR = 1.37，95%CI：1.06 - 1.77；P异质性 = 0.281）。这项荟萃分析表明，GSTO2多态性可能在白种人群中显著增加癌症风险，并与乳腺癌风险升高相关；而GSTO1多态性与癌症风险无关。
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