Chen Si, Wang Bingsong, Dong Ning, Ren Xiaofang, Zhang Tuohong, Xiao Lin
Department of Ophthalmology, Beijing Shijitan Hospital, Capital University of Medical Sciences, Peking, People's Republic of China.
School of Public Health, Peking University, Peking, People's Republic of China.
Invest Ophthalmol Vis Sci. 2014 Oct 14;55(11):7410-6. doi: 10.1167/iovs.14-13894.
To evaluate the macular thickness/volume in Chinese myopic children using spectral-domain optical coherence tomography (SD-OCT) and assess its correlation with spherical equivalent refraction (SER), axial length (AL), sex, and age.
A total of 194 eyes from 194 children (aged 6-17 years old) with emmetropia (-0.5 diopters [D] < SER ≤ 0.5 D), low myopia (-3.0 D < SER ≤ -0.5 D), and moderate to high myopia (SER ≤ -3.0 D) were recruited in the study. Each child underwent standardized ophthalmic examinations including visual acuity (VA), cycloplegic refraction, and AL measurement. The macular thickness for the nine Early Treatment Diabetic Retinopathy Study (ETDRS) regions and the average macular thickness/volume were measured and calculated.
Analyses of macular thickness for the ETDRS regions showed that the fovea was the thinnest of the nine regions, followed by the outer ring; the inner ring was the thickest. When compared to children with emmetropia or low myopia, children with moderate to high myopia tended to have greater foveal thickness, thinner quadrant-specific thickness in the outer ring, and smaller average macular thickness/volume. Also, there were significant differences in foveal, superior outer, inferior outer, and temporal outer quadrants among lowest, middle, and highest AL groups. Boys were found to have greater macular thickness than girls in fovea and inner ring regions.
Our study highlights the variations and sex differences of macular thickness/volume in Chinese myopic children using SD-OCT.
使用频域光学相干断层扫描（SD - OCT）评估中国近视儿童的黄斑厚度/体积，并评估其与等效球镜度（SER）、眼轴长度（AL）、性别和年龄的相关性。
本研究纳入了194名年龄在6 - 17岁的儿童的194只眼，这些儿童分别为正视眼（-0.5屈光度[D]< SER≤0.5 D）、低度近视（-3.0 D < SER≤ -0.5 D）和中度至高度近视（SER≤ -3.0 D）。每个儿童都接受了包括视力（VA）、散瞳验光和眼轴长度测量在内的标准化眼科检查。测量并计算了九个糖尿病视网膜病变早期治疗研究（ETDRS）区域的黄斑厚度以及平均黄斑厚度/体积。
对ETDRS区域黄斑厚度的分析表明，中央凹是九个区域中最薄的，其次是外环；内环最厚。与正视眼或低度近视儿童相比，中度至高度近视儿童的中央凹厚度往往更大，外环象限特异性厚度更薄，平均黄斑厚度/体积更小。此外，在最低、中等和最高眼轴长度组之间，中央凹、外上、外下和颞外侧象限存在显著差异。发现在中央凹和内环区域，男孩的黄斑厚度大于女孩。
我们的研究突出了使用SD - OCT测量的中国近视儿童黄斑厚度/体积的变化及性别差异。
