Laboratory of Clinical Virology, Institute Pasteur of Tunis, University of Tunis El Manar, Tunis, Tunisia.
J Med Virol. 2015 Mar;87(3):441-5. doi: 10.1002/jmv.24082. Epub 2014 Oct 20.
The aims of this study are to determine seroprevalence of Hepatitis E virus (HEV) in Tunisian blood donors and to evaluate its risk of parenteral transmission. Sera collected from 426 blood donors were tested for HEV IgG by indirect ELISA. Individuals were recruited from two national transfusion centers, in the North and the South of the country. Seroprevalence of HEV IgG was then compared with two other groups with increased risk of exposure to parenterally transmitted agents: 80 hemophiliac and 286 hemodialysis patients. Among blood donors, the seroprevalence was estimated to be 4.5%. It was significantly higher in the hemophiliac and hemodialysis groups with 7.5% and 10.2%, respectively, (P = 0.002). No significant correlation was observed for this IgG 1 seroprevalence between age and sex among three studied groups. These results suggest that HEV has a high risk of parenteral transmission and confirm that the low endemicity of hepatitis E in Tunisia was observed.
本研究旨在确定突尼斯献血者中戊型肝炎病毒（HEV）的血清流行率，并评估其经血液传播的风险。从 426 名献血者中采集的血清通过间接酶联免疫吸附试验（ELISA）检测 HEV IgG。这些个体来自该国北部和南部的两个国家输血中心。然后将 HEV IgG 的血清流行率与另外两组具有更高经血液传播因子暴露风险的组进行比较：80 名血友病患者和 286 名血液透析患者。在献血者中，血清流行率估计为 4.5%。在血友病和血液透析患者中，血清流行率分别为 7.5%和 10.2%，显著更高（P=0.002）。在这三组中，年龄和性别之间的这种 IgG1 血清流行率没有观察到显著相关性。这些结果表明，HEV 具有很高的经血液传播风险，并证实了突尼斯戊型肝炎的低流行率。
