系统性红斑狼疮中的甲状腺癌：一项荟萃分析。
Thyroid cancer in systemic lupus erythematosus: a meta analysis.
作者信息
Zhang Min, Li Xiao-Mei, Wang Guo-Sheng, Qian Long, Tao Jin-Hui, Ma Yan, Li Xiang-Pei
机构信息
Department of Rheumatology and Immunology, Anhui Provincial Hospital, Anhui Medical University Hefei 230001, P. R. China.
出版信息
Int J Clin Exp Pathol. 2014 Aug 15;7(9):6270-3. eCollection 2014.
OBJECTIVE
Considering inconclusive and heterogenous results, the aim of this study was to investigate the risk of thyroid cancer in systemic lupus erythematosus (SLE) by a quantitatively systematic review with meta-analysis.
METHODS
Electronic database of PubMed was searched for studies characterizing the associated risk of thyroid cancer in patients with SLE. The meta-analysis procedure was used to combine standardized incidence rates (SIRs) with 95% confidence intervals (CIs) to evaluate the association.
RESULTS
Seven cohort studies fulfilled the inclusion criteria and were subjected to the final analysis in the meta-analysis. Homogeneity was confirmed across the included studies. The pooled SIR based on a fixed-effect model was 2.22, with a 95% CI of 2.11-2.34. Sensitivity analyses suggested that the summary statistics obtained should approximate the actual average.
CONCLUSION
Findings from this meta-analysis revealed the positive association between thyroid cancer and SLE risk. Individuals with SLE have a heightened risk of developing thyroid cancer.
目的
鉴于结果尚无定论且存在异质性，本研究旨在通过定量系统评价和荟萃分析来调查系统性红斑狼疮（SLE）患者患甲状腺癌的风险。
方法
检索PubMed电子数据库中关于SLE患者甲状腺癌相关风险特征的研究。采用荟萃分析程序将标准化发病率（SIRs）与95%置信区间（CIs）相结合，以评估两者之间的关联。
结果
七项队列研究符合纳入标准，并在荟萃分析中进行最终分析。纳入研究间的同质性得到确认。基于固定效应模型的合并SIR为2.22，95%CI为2.11 - 2.34。敏感性分析表明，所获得的汇总统计数据应接近实际平均值。
结论
该荟萃分析的结果揭示了甲状腺癌与SLE风险之间的正相关。SLE患者患甲状腺癌的风险更高。
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